Patil, I. S.
Preparation, evaluation and optimization of mucoadhesive mini tablets of telmisartan by using single unit encapsulation system - Vol.56(5), May - Mumbai Indian Drug Manufacture's Association - IDMA 2019 - 64-67p.
The objective of the present study was to develop and optimize capsule filled oral mucoadhesive minitablets of telmisartan. Wet granulation method was employed for the development of minitablets. All the formulations (F1- F13) exhibited more than 21% drug release at 4h and at the end of 12h it showed drug release more than 90%. During the dissolution study it was observed that the capsule shell in which the minitablets were filled got completely dissolved in the first 5 min. FTIR and UV study showed absence of any significant physical and chemical interaction between drug and polymers. Formulation F 10 was found to possess higher drug release at 4h and 12 h. Combination of HPMC and Carbopol was found to be suitable for formulation of mucoadhesive minitablets, showed promising mucoadhesive strength and exhibited controlled drug release over an extended period of time.
PHARMACEUTICS
Preparation, evaluation and optimization of mucoadhesive mini tablets of telmisartan by using single unit encapsulation system - Vol.56(5), May - Mumbai Indian Drug Manufacture's Association - IDMA 2019 - 64-67p.
The objective of the present study was to develop and optimize capsule filled oral mucoadhesive minitablets of telmisartan. Wet granulation method was employed for the development of minitablets. All the formulations (F1- F13) exhibited more than 21% drug release at 4h and at the end of 12h it showed drug release more than 90%. During the dissolution study it was observed that the capsule shell in which the minitablets were filled got completely dissolved in the first 5 min. FTIR and UV study showed absence of any significant physical and chemical interaction between drug and polymers. Formulation F 10 was found to possess higher drug release at 4h and 12 h. Combination of HPMC and Carbopol was found to be suitable for formulation of mucoadhesive minitablets, showed promising mucoadhesive strength and exhibited controlled drug release over an extended period of time.
PHARMACEUTICS