Ahuja, Brijbhushan
Proline catalyzed sequential α-amination/ Prins/ Ritter amidation of aldehydes : new method of construction of tetrahydropyran units - Vol.58B(9), Sep - New Delhi CSIR 2019 - 1019-1028p.
An efficient “one-pot” synthetic method toward highly substituted tetrahydrofuran (THP) units is reported. The key transformation involves an atom-efficient sequential proline catalyzed α-amination of aldehydes to give α-aminated aldehydes in situ and the subsequent cyclomerization with homoallylic alcohols under Prins/Ritter conditions. Notably, this method provides access to enantiopure 1,2-syn and 1,4-anti diamino alcohols via reductive ring opening of THP units.
GENERAL CHEMISTRY
Proline catalyzed sequential α-amination/ Prins/ Ritter amidation of aldehydes : new method of construction of tetrahydropyran units - Vol.58B(9), Sep - New Delhi CSIR 2019 - 1019-1028p.
An efficient “one-pot” synthetic method toward highly substituted tetrahydrofuran (THP) units is reported. The key transformation involves an atom-efficient sequential proline catalyzed α-amination of aldehydes to give α-aminated aldehydes in situ and the subsequent cyclomerization with homoallylic alcohols under Prins/Ritter conditions. Notably, this method provides access to enantiopure 1,2-syn and 1,4-anti diamino alcohols via reductive ring opening of THP units.
GENERAL CHEMISTRY