Osman, Zuhaeir
INFLUENCE OF BINDING SOLUTION CONCENTRATION, DRYING DURATION AND DRYING TEMPERATURE ON PHYSIOCHEMICAL PERFORMANCE OF NORFLO XACIN GRANULES AND TABLETS - Vol.11(10) - M P Innovare Academic Sciences Pvt Ltd 2019 - 71-79p.
Objective
:
To investigate the possible individual and joined i
nfluences that binding solution concentration, dryi
ng temperature and drying duration
might have on the physiochemical attributes of gran
ules and tablets using norfloxacin as a model drug.
Methods
:
According to implemented 2
3
central composite designs, each of the investigate
d variables were examined at 5 different levels thr
ough
different 16 formulation runs. For each formulation
, obtained granules were qualified for their bulk d
ensity, tap density, Hausner ratio, percent of
fine and drug content properties whereas the respec
tive tablets were evaluated for their weight variat
ion, drug content, friability, hardness,
disintegration, and drug dissolution attributes.
Results:
Indicated that concentration of binder solution, as
compared to drying temperature and drying duration
, measured more profound
influences on granules' tap density, Hausner ratio,
% fine and drug content either through its individu
al linear and quadratic effects or through its
joint effect with drying durations (p<0.05 at 95% C
I for all influences). Whilst tablets' friability a
ppeared to be noticeably influenced by the three
investigated variables (P ranged 0.001-0.017 at 95%
CI), tablets' hardness and disintegration were fou
nd to be considerably affected only by binder
solution concentration (p = 0.001 and 0.082 at 95%
CI, respectively). Moreover, none of the investigat
ed variables has measured a significant
influence on tablets' drug content or drug dissolut
ion properties.
Conclusion:
The study concluded that quadratic and joint influe
nces of variables on attributes of granule and tabl
et formulations shouldn't be
overlooked and better to be considered in the scree
ning design.
PHARMACEUTICS
INFLUENCE OF BINDING SOLUTION CONCENTRATION, DRYING DURATION AND DRYING TEMPERATURE ON PHYSIOCHEMICAL PERFORMANCE OF NORFLO XACIN GRANULES AND TABLETS - Vol.11(10) - M P Innovare Academic Sciences Pvt Ltd 2019 - 71-79p.
Objective
:
To investigate the possible individual and joined i
nfluences that binding solution concentration, dryi
ng temperature and drying duration
might have on the physiochemical attributes of gran
ules and tablets using norfloxacin as a model drug.
Methods
:
According to implemented 2
3
central composite designs, each of the investigate
d variables were examined at 5 different levels thr
ough
different 16 formulation runs. For each formulation
, obtained granules were qualified for their bulk d
ensity, tap density, Hausner ratio, percent of
fine and drug content properties whereas the respec
tive tablets were evaluated for their weight variat
ion, drug content, friability, hardness,
disintegration, and drug dissolution attributes.
Results:
Indicated that concentration of binder solution, as
compared to drying temperature and drying duration
, measured more profound
influences on granules' tap density, Hausner ratio,
% fine and drug content either through its individu
al linear and quadratic effects or through its
joint effect with drying durations (p<0.05 at 95% C
I for all influences). Whilst tablets' friability a
ppeared to be noticeably influenced by the three
investigated variables (P ranged 0.001-0.017 at 95%
CI), tablets' hardness and disintegration were fou
nd to be considerably affected only by binder
solution concentration (p = 0.001 and 0.082 at 95%
CI, respectively). Moreover, none of the investigat
ed variables has measured a significant
influence on tablets' drug content or drug dissolut
ion properties.
Conclusion:
The study concluded that quadratic and joint influe
nces of variables on attributes of granule and tabl
et formulations shouldn't be
overlooked and better to be considered in the scree
ning design.
PHARMACEUTICS