Yasmin Begum, M.
FORMULATION AND EVALUATION OF DASATINIB LOADED SOLID LIPID NANOPARTICLES - Vol.10(12) - M P Innovare Academic Sciences Pvt Ltd 2018 - 14-20p.
Objective:
Method
s:
SLNs consist of a solid lipid matrix
where the drug
was
incorporated
. Surfactants of GRAS grade were used t
o avoid aggregation and to
stabilize the SLNs.
DST
-SLN
s formulations of varying con
centrations were prepared by high
-speed
homogenization technique and evaluated for
drug excipients compatibility study, poly
-dispersity index, particle size analysis, surface
morphology, zeta potential
, and
drug release features.
The aim of present work wa
s to formulate and
evaluate
Dasatinib
(DST)
loaded solid lipid nanoparticles
(SLNs)
as a potential antic
ancer
drug delivery system
by enhancing its solubility.
Result
s:
It was observed that
DST
-SLNs with optimum
quantities o
f poloxome
r: lecithin ratio showed 88.06% drug release
in 6h
with good
entrapment efficiency of 76.9±0.84 %
. Particle size, Polydispersity
index, zeta potential and drug entrapment efficiency for the optimized
formula
tion was found to be
optimum
. Stability studies
revealed that the entrapment efficiency of the SLN dispersion stored in 4
°C was stable.
Conclusio
n
:
Thus, it can be concluded that
the
formulations
of
DST loaded SLNs
are suitable carriers for improving the
solubility and dissolution
related problems.
PHARMACEUTICS
FORMULATION AND EVALUATION OF DASATINIB LOADED SOLID LIPID NANOPARTICLES - Vol.10(12) - M P Innovare Academic Sciences Pvt Ltd 2018 - 14-20p.
Objective:
Method
s:
SLNs consist of a solid lipid matrix
where the drug
was
incorporated
. Surfactants of GRAS grade were used t
o avoid aggregation and to
stabilize the SLNs.
DST
-SLN
s formulations of varying con
centrations were prepared by high
-speed
homogenization technique and evaluated for
drug excipients compatibility study, poly
-dispersity index, particle size analysis, surface
morphology, zeta potential
, and
drug release features.
The aim of present work wa
s to formulate and
evaluate
Dasatinib
(DST)
loaded solid lipid nanoparticles
(SLNs)
as a potential antic
ancer
drug delivery system
by enhancing its solubility.
Result
s:
It was observed that
DST
-SLNs with optimum
quantities o
f poloxome
r: lecithin ratio showed 88.06% drug release
in 6h
with good
entrapment efficiency of 76.9±0.84 %
. Particle size, Polydispersity
index, zeta potential and drug entrapment efficiency for the optimized
formula
tion was found to be
optimum
. Stability studies
revealed that the entrapment efficiency of the SLN dispersion stored in 4
°C was stable.
Conclusio
n
:
Thus, it can be concluded that
the
formulations
of
DST loaded SLNs
are suitable carriers for improving the
solubility and dissolution
related problems.
PHARMACEUTICS