Mao, Xiuhua
Inhibitory effect of hydroxysafflor yellow pigment a on human gastric adenocarcinoma BGC-823 xenograft in nude mice - Vol.83(2), March-April - Mumbai Indian Journal of Pharmaceutical Science 2021 - 362-370p.
In China, the incidence rate and mortality rate of gastric cancer are in the second place among all tumors
and the pathological type is mainly adenocarcinoma. The higher prevalence rate requires us to do more
research. It is of great signi ficance to study the antitumor e ffect of hydroxysa fflor yellow pigment A in
gastric adenocarcinoma. The aim of this study was to investigate the inhibitory e ffect of hydroxysa fflor
yellow pigment A on human gastric adenocarcinoma BGC-823 xenograft in nude mice. The animal model
of human gastric adenocarcinoma BGC-823 was established in nude mice to carry out the experiment and
then the transmission electron microscope was used to observe and analyze the experimental data. The
results showed that on the 4 th d after inoculation, there were more subcutaneous tumor masses in nude
mice and on the 7 th d, all the nude mice formed tumor blocks with the size of 0.4 cm to 0.8 cm and the
tumorigenesis rate was 100 %. With the continuous administration, the tumor weight of the small dose
group was only 0.88 g, which was much smaller than that of the model group. The average percentage of
early apoptosis in low dose group was 2.48 % and that in model group was 0.44 %. In the low dose group, the
volume of tumor cells became smaller and apoptotic bodies appeared. Therefore, it is of great significance
to study the inhibitory effect of hydroxysafflor yellow pigment A on human gastric adenocarcinoma BGC-
823 xenograft in nude mice.
PHARMACEUTICS
Inhibitory effect of hydroxysafflor yellow pigment a on human gastric adenocarcinoma BGC-823 xenograft in nude mice - Vol.83(2), March-April - Mumbai Indian Journal of Pharmaceutical Science 2021 - 362-370p.
In China, the incidence rate and mortality rate of gastric cancer are in the second place among all tumors
and the pathological type is mainly adenocarcinoma. The higher prevalence rate requires us to do more
research. It is of great signi ficance to study the antitumor e ffect of hydroxysa fflor yellow pigment A in
gastric adenocarcinoma. The aim of this study was to investigate the inhibitory e ffect of hydroxysa fflor
yellow pigment A on human gastric adenocarcinoma BGC-823 xenograft in nude mice. The animal model
of human gastric adenocarcinoma BGC-823 was established in nude mice to carry out the experiment and
then the transmission electron microscope was used to observe and analyze the experimental data. The
results showed that on the 4 th d after inoculation, there were more subcutaneous tumor masses in nude
mice and on the 7 th d, all the nude mice formed tumor blocks with the size of 0.4 cm to 0.8 cm and the
tumorigenesis rate was 100 %. With the continuous administration, the tumor weight of the small dose
group was only 0.88 g, which was much smaller than that of the model group. The average percentage of
early apoptosis in low dose group was 2.48 % and that in model group was 0.44 %. In the low dose group, the
volume of tumor cells became smaller and apoptotic bodies appeared. Therefore, it is of great significance
to study the inhibitory effect of hydroxysafflor yellow pigment A on human gastric adenocarcinoma BGC-
823 xenograft in nude mice.
PHARMACEUTICS