Jadhav, V. V.
Formulation and evaluation of mesoporous silica nanoparticle loaded fast dissolving tablet of tamoxifen - Vol.83(1), Jan-Feb - Mumbai Indian Journal of Pharmaceutical Science 2021 - 32-38p.
Breast cancer is a cancer which has significant societal impact because it generally affects the young age
people. Tamoxifen is Biopharmaceutical Classification System class II drug. This active pharmaceutical
ingredient have problem with solubility. Most of the anti-cancerous drugs have problem with solubility
because of their complicated structures. To deal with this problem mesoporous silica nanoparticles of
tamoxifen are prepared. Drug entrapped in mesoporous structure which is having size less than 200
nm. It leads to improvement in solubility and further bioavailability. Various studies after formulation
show improvement in solubility and decrease in particle size. Further fast dissolving tablet is prepared to
improve bioavailability. Pre compression studies and post compression studies show tablet dissolve within
30 s. Hence mesoporous silica nanoparticles are best way to improve solubility
PHARMACEUTICS
Formulation and evaluation of mesoporous silica nanoparticle loaded fast dissolving tablet of tamoxifen - Vol.83(1), Jan-Feb - Mumbai Indian Journal of Pharmaceutical Science 2021 - 32-38p.
Breast cancer is a cancer which has significant societal impact because it generally affects the young age
people. Tamoxifen is Biopharmaceutical Classification System class II drug. This active pharmaceutical
ingredient have problem with solubility. Most of the anti-cancerous drugs have problem with solubility
because of their complicated structures. To deal with this problem mesoporous silica nanoparticles of
tamoxifen are prepared. Drug entrapped in mesoporous structure which is having size less than 200
nm. It leads to improvement in solubility and further bioavailability. Various studies after formulation
show improvement in solubility and decrease in particle size. Further fast dissolving tablet is prepared to
improve bioavailability. Pre compression studies and post compression studies show tablet dissolve within
30 s. Hence mesoporous silica nanoparticles are best way to improve solubility
PHARMACEUTICS