Harsahay, Meena
Evaluation of involvement of neuro-chemical mechanism in valeriana wallichiiinduced original articleantidepressant effectin mice - Vol.13(5) - M P Innovare Academic Sciences Pvt Ltd 2021 - 11-17p.
Objective:Valeriana (V) wallichii DC is found among the ground flora of Himalayan regions and used as herbal medicine for CNS disorders in Indian systems of medicine. In the study, aimed to investigation of involvement of neuro-chemical-systems in V. wallichii induced antidepressant effects in mice. Methods:The antidepressant activity of aqueous alcoholic extracts of V. wallichiiwas measured by using Forced Swim Test and Tail Suspension Test in mice, whereas locomotor activity was observed by Actophotometer. Involvement of adrenergic, dopaminergic and serotonergic receptors in V. wallichiiinduced antidepressant effects in mice were also observed. Results:Sub-acute administration of V. wallichiiin mice showed significant (P<0.05) increase in the antidepressant activity similar to the Imipramine, but did not show at lower doses in FST. Whereas, pretreatment of adrenergic receptor antagonist, dopaminergic receptor antagonist and serotonin synthesis inhibitor preventedV. wallichii induce anti-depressant effect in mice. Lower doses of hydoalcoholic extract of V. wallichiidid not interfering the locomotor activity in mice during the sub-acute administration, but at a higher dose significantly (P<0.05) decreases the locomotor activity. Conclusion:Hence, it is concluded that the antidepressant effect of V. wallichii in mice may mediate via adrenergic, dopaminergic and serotonergic systems.
PHARMACEUTICS
Evaluation of involvement of neuro-chemical mechanism in valeriana wallichiiinduced original articleantidepressant effectin mice - Vol.13(5) - M P Innovare Academic Sciences Pvt Ltd 2021 - 11-17p.
Objective:Valeriana (V) wallichii DC is found among the ground flora of Himalayan regions and used as herbal medicine for CNS disorders in Indian systems of medicine. In the study, aimed to investigation of involvement of neuro-chemical-systems in V. wallichii induced antidepressant effects in mice. Methods:The antidepressant activity of aqueous alcoholic extracts of V. wallichiiwas measured by using Forced Swim Test and Tail Suspension Test in mice, whereas locomotor activity was observed by Actophotometer. Involvement of adrenergic, dopaminergic and serotonergic receptors in V. wallichiiinduced antidepressant effects in mice were also observed. Results:Sub-acute administration of V. wallichiiin mice showed significant (P<0.05) increase in the antidepressant activity similar to the Imipramine, but did not show at lower doses in FST. Whereas, pretreatment of adrenergic receptor antagonist, dopaminergic receptor antagonist and serotonin synthesis inhibitor preventedV. wallichii induce anti-depressant effect in mice. Lower doses of hydoalcoholic extract of V. wallichiidid not interfering the locomotor activity in mice during the sub-acute administration, but at a higher dose significantly (P<0.05) decreases the locomotor activity. Conclusion:Hence, it is concluded that the antidepressant effect of V. wallichii in mice may mediate via adrenergic, dopaminergic and serotonergic systems.
PHARMACEUTICS