Junutula, Srinivas Pramod
Therapeutic drug monitoring of olanzapine: Easy and reliable method for clinical correlation - Vol.53(1), Jan-Feb - Mumbai Wolter Kluwer 2021 - 2-5p.
AIM: The current work establishes an easy, reliable technique for the estimation of serum Olanzapine
concentration which correlates it clinically.
SUBJECTS AND METHODS: The work was agreed in 61 schizophrenic patients who were
on olanzapine. Serum drug amount was estimated by normal‑phase high‑performance liquid
chromatography and brief psychiatry rating scale was used to determine disease progression.
RESULTS: Samples provided 61 patients, 40 were under sub‑therapeutic range, 18 were under
therapeutic range and 3 were above the therapeutic range.
CONCLUSION: Therapeutic drug monitoring must be a part of clinical practice in psychiatric hospitals
for optimizing the dose of an individual patient along with the correlation of serum concentration with
the clinical assessment scales.
PHARMACOLOGY
Therapeutic drug monitoring of olanzapine: Easy and reliable method for clinical correlation - Vol.53(1), Jan-Feb - Mumbai Wolter Kluwer 2021 - 2-5p.
AIM: The current work establishes an easy, reliable technique for the estimation of serum Olanzapine
concentration which correlates it clinically.
SUBJECTS AND METHODS: The work was agreed in 61 schizophrenic patients who were
on olanzapine. Serum drug amount was estimated by normal‑phase high‑performance liquid
chromatography and brief psychiatry rating scale was used to determine disease progression.
RESULTS: Samples provided 61 patients, 40 were under sub‑therapeutic range, 18 were under
therapeutic range and 3 were above the therapeutic range.
CONCLUSION: Therapeutic drug monitoring must be a part of clinical practice in psychiatric hospitals
for optimizing the dose of an individual patient along with the correlation of serum concentration with
the clinical assessment scales.
PHARMACOLOGY