Sil. A.
Nutraceutical and cosmeceutical potential of seaweed derived fucoxanthin - Vol.83(4), Jul-Aug - Mumbai Indian Journal of Pharmaceutical Science 2021 - 618-633p.
The marine ecosystem is considered a potentially mysterious reservoir of biodiversity consisting of a
broad spectrum of bioactive constituents, whose potential is still under research for pharmaceuticals,
nutraceuticals and cosmeceuticals. Fucoxanthin, a carotenoid, can be found in the brown seaweeds and is
recognized to show promising and exclusive biological activities. Subsequent consumption and absorption
of fucoxanthin leads to its accumulation in the white adipose tissue and helps to depict anti-obesity effects
via upregulation of thermogenesis through uncoupling protein 1 expression and mitochondrial activation.
Linking with anti-obesity, fucoxanthin shows antidiabetic potential by insulin resistance signalling
pathways. Fucoxanthin is also reported to control carcinogenesis via regulating several biomolecules and
signalling pathways which are intermittently linked with either apoptosis or cell cycle arrest or suppression
of metastasis. In addition, it can act as a potential antioxidant by scavenging toxic free radicals and also
aid in the treatment of neurodegenerative, hepatic and cardiovascular dysfunctions. Fucoxanthin has a
profound role in the cosmetic industry for its mosquito repellent activity and protective effects on the blood
vessels, skin and bones. Therefore, the current review provides the recent available scientific literature on
Fucoxanthin regarding its health-promoting effects, modulating mechanism and future potential to use it
as a commercially viable drug in nutraceutical and cosmeceutical applications.
PHARMACEUTICS
Nutraceutical and cosmeceutical potential of seaweed derived fucoxanthin - Vol.83(4), Jul-Aug - Mumbai Indian Journal of Pharmaceutical Science 2021 - 618-633p.
The marine ecosystem is considered a potentially mysterious reservoir of biodiversity consisting of a
broad spectrum of bioactive constituents, whose potential is still under research for pharmaceuticals,
nutraceuticals and cosmeceuticals. Fucoxanthin, a carotenoid, can be found in the brown seaweeds and is
recognized to show promising and exclusive biological activities. Subsequent consumption and absorption
of fucoxanthin leads to its accumulation in the white adipose tissue and helps to depict anti-obesity effects
via upregulation of thermogenesis through uncoupling protein 1 expression and mitochondrial activation.
Linking with anti-obesity, fucoxanthin shows antidiabetic potential by insulin resistance signalling
pathways. Fucoxanthin is also reported to control carcinogenesis via regulating several biomolecules and
signalling pathways which are intermittently linked with either apoptosis or cell cycle arrest or suppression
of metastasis. In addition, it can act as a potential antioxidant by scavenging toxic free radicals and also
aid in the treatment of neurodegenerative, hepatic and cardiovascular dysfunctions. Fucoxanthin has a
profound role in the cosmetic industry for its mosquito repellent activity and protective effects on the blood
vessels, skin and bones. Therefore, the current review provides the recent available scientific literature on
Fucoxanthin regarding its health-promoting effects, modulating mechanism and future potential to use it
as a commercially viable drug in nutraceutical and cosmeceutical applications.
PHARMACEUTICS