Pramanik, Arunima
Characterization and molecular docking of kaolin based cellulosic film for extending ophthalmic drug delivery - Vol.83(4), July-Aug - Mumbai Indian Journal of Pharmaceutical Science 2021 - 794-807p.
Ophthalmic delivery of dexamethasone can control inflammation and also some forms of uveitis. But it is
effective therapeutically over a short period of time and frequent instillation is required. Hydroxypropyl
methylcellulose matrix films containing dexamethasone were prepared by casting method in presence
and absence of particulate kaolin for extending ophthalmic drug delivery. Fourier-transform infrared
spectroscopy confirmed the complexation of dexamethasone and kaolin in the film via formation
of hydrogen bond and the observed shouldering at 1032 cm -1 increased with corresponding higher
amount of kaolin binding. Differential scanning calorimetry thermogram resulted in almost complete
amorphization of dexamethasone in the film. X-ray diffractogram demonstrated almost disappearance of
kaolinite diffraction and the reduced order of dexamethasone crystal lattice in all the film formulations.
Submicrons, tubular and nano-fibrous morphology of the kaolin and drug particles were seen in the
scanning electron microscope images of the film. Relatively extended diffusion controlled drug release
and ophthalmic permeation behavior were observed with the increase of kaolin loading in the film. Stable
complex facilitated the sustained ophthalmic delivery of dexamethasone and prolonged anti-inflammatory
activity. Molecular docking study also revealed the complex formation of dexamethasone with kaolin
and hydroxypropyl methyl cellulose to understand the fitting and stable configuration of drug-carrier
interaction. Kaolin-based hydroxypropyl methyl cellulose hydrogel film containing dexamethasone as a
model drug can enhance the corneal residence time for anti-inflammation for an extended period of time.
PHARMACEUTICS
Characterization and molecular docking of kaolin based cellulosic film for extending ophthalmic drug delivery - Vol.83(4), July-Aug - Mumbai Indian Journal of Pharmaceutical Science 2021 - 794-807p.
Ophthalmic delivery of dexamethasone can control inflammation and also some forms of uveitis. But it is
effective therapeutically over a short period of time and frequent instillation is required. Hydroxypropyl
methylcellulose matrix films containing dexamethasone were prepared by casting method in presence
and absence of particulate kaolin for extending ophthalmic drug delivery. Fourier-transform infrared
spectroscopy confirmed the complexation of dexamethasone and kaolin in the film via formation
of hydrogen bond and the observed shouldering at 1032 cm -1 increased with corresponding higher
amount of kaolin binding. Differential scanning calorimetry thermogram resulted in almost complete
amorphization of dexamethasone in the film. X-ray diffractogram demonstrated almost disappearance of
kaolinite diffraction and the reduced order of dexamethasone crystal lattice in all the film formulations.
Submicrons, tubular and nano-fibrous morphology of the kaolin and drug particles were seen in the
scanning electron microscope images of the film. Relatively extended diffusion controlled drug release
and ophthalmic permeation behavior were observed with the increase of kaolin loading in the film. Stable
complex facilitated the sustained ophthalmic delivery of dexamethasone and prolonged anti-inflammatory
activity. Molecular docking study also revealed the complex formation of dexamethasone with kaolin
and hydroxypropyl methyl cellulose to understand the fitting and stable configuration of drug-carrier
interaction. Kaolin-based hydroxypropyl methyl cellulose hydrogel film containing dexamethasone as a
model drug can enhance the corneal residence time for anti-inflammation for an extended period of time.
PHARMACEUTICS