Saini, Ramakrishna
Green method for the synthesis of isoxazolyl aryl thieno[2,3-d]pyrimidinones using reusable polyethylene glycol as simple solvent catalyst and evaluation of anti-microbial activity - Vol.61(3), Mar - New Delhi CSIR 2022 - 336-347p.
Novel series of isoxazolyl aryl thieno[2,3-d]pyrimidinones 4 have been synthesized from (E)-2-amino-5-(3-methyl-4-nitroisoxazol-5-yl)-N-(3-methyl-5-styrylisoxazol-4-yl)-4-arylthiophene-3-carboxamide synthon 3. Compound 3 is obtained by reaction of 2-(3-methyl-4-nitro-isoxazol-5-yl)-1-aryl-ethanone 1, N1--2-cyanoacetamide 2 and elemental sulfur in PEG-400. Isoxazolyl aryl thieno[2,3-d]pyrimidinones 4 have been obtained from compounds 3 by tandem N-acetylation and cyclodehydration with acetic anhydride. Compounds 3a-q and 4a-q have been characterized by IR, 1H and 13C NMR, and mass spectral data. The title compounds 4a-q have been evaluated for their antimicrobial activity. Compounds 4b, 4c, 4d, 4e, 4j, 4k, 4l and 4m exhibit significant antimicrobial activity, compared to that of standard drugs.
GENERAL CHEMISTRY
Green method for the synthesis of isoxazolyl aryl thieno[2,3-d]pyrimidinones using reusable polyethylene glycol as simple solvent catalyst and evaluation of anti-microbial activity - Vol.61(3), Mar - New Delhi CSIR 2022 - 336-347p.
Novel series of isoxazolyl aryl thieno[2,3-d]pyrimidinones 4 have been synthesized from (E)-2-amino-5-(3-methyl-4-nitroisoxazol-5-yl)-N-(3-methyl-5-styrylisoxazol-4-yl)-4-arylthiophene-3-carboxamide synthon 3. Compound 3 is obtained by reaction of 2-(3-methyl-4-nitro-isoxazol-5-yl)-1-aryl-ethanone 1, N1--2-cyanoacetamide 2 and elemental sulfur in PEG-400. Isoxazolyl aryl thieno[2,3-d]pyrimidinones 4 have been obtained from compounds 3 by tandem N-acetylation and cyclodehydration with acetic anhydride. Compounds 3a-q and 4a-q have been characterized by IR, 1H and 13C NMR, and mass spectral data. The title compounds 4a-q have been evaluated for their antimicrobial activity. Compounds 4b, 4c, 4d, 4e, 4j, 4k, 4l and 4m exhibit significant antimicrobial activity, compared to that of standard drugs.
GENERAL CHEMISTRY