Yu, X.
Bilobalide protects pheochromocytoma cell from oxygen-glucose deprivation/reperfusion induced injury via activating Wnt1/beta catenin pathway - Vol.84(5), Sep-Oct - Mumbai Indian Journal of Pharmaceutical Science 2022 - 1323-1327p.
To explore the protective effect of bilobalide on the pheochromocytoma cell injury induced by
oxygen-glucose deprivation/reperfusion in vitro. To simulate ischemia-reperfusion condition, the
pheochromocytoma cell injury was induced by oxygen-glucose deprivation/reperfusion in vitro. The
cells were divided into control, oxygen-glucose deprivation/reperfusion and oxygen-glucose deprivation/
reperfusion+bilobalide groups. The cell viability, proliferative capacity, malondialdehyde level, superoxide
dismutase level, apoptosis, Wnt1 protein level and nuclear beta-catenin protein level were assayed.
Compared with control group, the cell viability, proliferative capacity, superoxide dismutase level,
Wnt1 protein level and nuclear beta-catenin protein level decreased in the oxygen-glucose deprivation/
reperfusion group, malondialdehyde level and the percentage of apoptotic cells increased in the oxygen-
glucose deprivation/reperfusion group, while the cells were treated with bilobalide in the oxygen-glucose
deprivation/reperfusion+bilobalide group, all the above-mentioned observation indicators recovered to a
certain extent, but still did not reach the level of the control group. Bilobalide protects pheochromocytoma
cell from oxygen-glucose deprivation/reperfusion induced injury in vitro through inhibiting oxidative
stress via activating Wnt1/beta-catenin pathway.
PHARMACEUTICS
Bilobalide protects pheochromocytoma cell from oxygen-glucose deprivation/reperfusion induced injury via activating Wnt1/beta catenin pathway - Vol.84(5), Sep-Oct - Mumbai Indian Journal of Pharmaceutical Science 2022 - 1323-1327p.
To explore the protective effect of bilobalide on the pheochromocytoma cell injury induced by
oxygen-glucose deprivation/reperfusion in vitro. To simulate ischemia-reperfusion condition, the
pheochromocytoma cell injury was induced by oxygen-glucose deprivation/reperfusion in vitro. The
cells were divided into control, oxygen-glucose deprivation/reperfusion and oxygen-glucose deprivation/
reperfusion+bilobalide groups. The cell viability, proliferative capacity, malondialdehyde level, superoxide
dismutase level, apoptosis, Wnt1 protein level and nuclear beta-catenin protein level were assayed.
Compared with control group, the cell viability, proliferative capacity, superoxide dismutase level,
Wnt1 protein level and nuclear beta-catenin protein level decreased in the oxygen-glucose deprivation/
reperfusion group, malondialdehyde level and the percentage of apoptotic cells increased in the oxygen-
glucose deprivation/reperfusion group, while the cells were treated with bilobalide in the oxygen-glucose
deprivation/reperfusion+bilobalide group, all the above-mentioned observation indicators recovered to a
certain extent, but still did not reach the level of the control group. Bilobalide protects pheochromocytoma
cell from oxygen-glucose deprivation/reperfusion induced injury in vitro through inhibiting oxidative
stress via activating Wnt1/beta-catenin pathway.
PHARMACEUTICS