Darnifayanti, Darnifayanti
Genetic polymorphisms associated with sepsis incidence, severity, and outcomes among neonates: A mini‑review - Vol.14(4), Oct-Dec - Mumbai Wolter Kluwer 2023 - 289-293p.
Genetic variation remains a topic of great interest due to its potential as a risk factor
for various diseases. Interactions between genes contribute to diverse phenotypes in
response to factors such as infection. The impact of genetic background on susceptibility
and clinical outcomes, particularly in neonatal sepsis, has gained recognition. The
variability in sepsis susceptibility and outcomes can be attributed to the genetic diversity
in coding regions and regulatory elements of genes related to innate immune response.
Recent advances in genomics and technology have shed light on genetic polymorphisms
among humans, often represented by single‑nucleotide polymorphisms (SNPs).
These SNPs encode proteins crucial for recognizing and responding to pathogenic
bacteria, including Toll‑like receptor 4, CD14, tumor necrosis factor‑alpha, as well
as interleukin‑1‑10. This literature review specifically discusses the involvement of
genetic polymorphism during the pathogenesis stage of sepsis, with an emphasis on
previous research findings in neonatal sepsis cases, aiming to discuss the implications
of polymorphism in sepsis susceptibility and outcomes.
PHARMACEUTICS
Genetic polymorphisms associated with sepsis incidence, severity, and outcomes among neonates: A mini‑review - Vol.14(4), Oct-Dec - Mumbai Wolter Kluwer 2023 - 289-293p.
Genetic variation remains a topic of great interest due to its potential as a risk factor
for various diseases. Interactions between genes contribute to diverse phenotypes in
response to factors such as infection. The impact of genetic background on susceptibility
and clinical outcomes, particularly in neonatal sepsis, has gained recognition. The
variability in sepsis susceptibility and outcomes can be attributed to the genetic diversity
in coding regions and regulatory elements of genes related to innate immune response.
Recent advances in genomics and technology have shed light on genetic polymorphisms
among humans, often represented by single‑nucleotide polymorphisms (SNPs).
These SNPs encode proteins crucial for recognizing and responding to pathogenic
bacteria, including Toll‑like receptor 4, CD14, tumor necrosis factor‑alpha, as well
as interleukin‑1‑10. This literature review specifically discusses the involvement of
genetic polymorphism during the pathogenesis stage of sepsis, with an emphasis on
previous research findings in neonatal sepsis cases, aiming to discuss the implications
of polymorphism in sepsis susceptibility and outcomes.
PHARMACEUTICS