Renal Cortical Structural Alterations in Atorvastatin-treated Rats and the Possible Protective Mechanisms of L-Carnitine (Record no. 10652)

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fixed length control field a
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control field OSt
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20191221120757.0
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fixed length control field 191221b xxu||||| |||| 00| 0 eng d
040 ## - CATALOGING SOURCE
Original cataloging agency AIKTC-KRRC
Transcribing agency AIKTC-KRRC
100 ## - MAIN ENTRY--PERSONAL NAME
9 (RLIN) 11339
Author Sahar, Youssef
245 ## - TITLE STATEMENT
Title Renal Cortical Structural Alterations in Atorvastatin-treated Rats and the Possible Protective Mechanisms of L-Carnitine
250 ## - EDITION STATEMENT
Volume, Issue number Vol. 81 (05)
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Place of publication, distribution, etc. Mumbai
Name of publisher, distributor, etc. Indian Journal of Pharmaceutical Science
Year 2019
300 ## - PHYSICAL DESCRIPTION
Pagination 834-842p.
520 ## - SUMMARY, ETC.
Summary, etc. The present study investigated the structural changes in rat kidney following administration of atorvastatin and evaluated the possible protective role of L-carnitine. Rats were divided into four groups, group I- control group, group II received L-carnitine at 100 mg/kg/d, group III received atorvastatin at 80 mg/kg/d and group IV received atorvastatin plus L-carnitine. Hematoxylin and Eosin, periodic acid-Schiff, inducible nitric oxide synthase, proliferating cell nuclear antigen expression and electron microscopy investigation were performed. Light microscopy results of atorvastatin group showed severe atrophic glomeruli with widened glomerular spaces. Some renal tubules showed cytoplasmic vacuolations, loss of brush borders, hemorrhage and mild congested blood capillaries. Strong positive inducible nitric oxide synthase and proliferating cell nuclear antigen immunostaining in the tubules were observed. Ultrastructurally, the proximal convoluted tubules had small electron dense nuclei, numerous lysosomes, partial loss of microvilli and vacuolations. The podocytes revealed united foot processes and increase in the thickness of the glomerular basement membrane. L-carnitine preserved the structure of renal cortex, decreased inducible nitric oxide synthase and increased proliferating cell nuclear antigen reaction. In conclusion, atorvastatin exerted a deleterious effect and L-carnitine improved most of the histological changes produced by atorvastatin.
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM
9 (RLIN) 4639
Topical term or geographic name entry element PHARMACEUTICS
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9 (RLIN) 11340
Co-Author Marwa Salah
773 0# - HOST ITEM ENTRY
Place, publisher, and date of publication New Delhi Indian Pharmaceutical Association
International Standard Serial Number 0250-474X
Title Indian journal of pharmaceutical sciences
856 ## - ELECTRONIC LOCATION AND ACCESS
URL http://www.ijpsonline.com/articles/renal-cortical-structural-alterations-in-atorvastatintreated-rats-and-the-possible-protective-mechanisms-of-lcarnitine-3697.html
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Koha item type Articles Abstract Database
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Withdrawn status Lost status Source of classification or shelving scheme Damaged status Not for loan Permanent Location Current Location Shelving location Date acquired Barcode Date last seen Price effective from Koha item type
          School of Pharmacy School of Pharmacy Archieval Section 2019-12-21 2020561 2019-12-21 2019-12-21 Articles Abstract Database
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