| 000 -LEADER |
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| fixed length control field |
a |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20191230122611.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
191230b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
AIKTC-KRRC |
| Transcribing agency |
AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME |
|---|
| 9 (RLIN) |
11444 |
| Author |
Hassan, Nazia |
| 245 ## - TITLE STATEMENT |
|---|
| Title |
Taste Masking of Levofloxacin by Microparticulate System Using Emulsion Solvent Evaporation Technique |
| 250 ## - EDITION STATEMENT |
|---|
| Volume, Issue number |
Vol. 81 (05) |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Mumbai |
| Name of publisher, distributor, etc. |
Indian Journal of Pharmaceutical Science |
| Year |
2019 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Pagination |
843-850p. |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
The preparation of microspheres by emulsion solvent evaporation technique has become an area of considerable attention in pharmaceutical industry. In the present study, investigation reports the formulation of microspheres of levofloxacin using ethyl cellulose and Eudragit L100 in order to mask the bitter taste of drug. Ten microsphere formulations F1 to F10 were fabricated by varying the ratio of polymers at different stirring speed (700-850 rpm). Particle size, shape, flow properties, encapsulation efficiency and in vitro release profile of the prepared microspheres were studied. Fourier-transform infrared spectroscopy and differential scanning calorimetry showed no significant drug polymer interaction. Kinetic modeling results demonstrated that release data was best fit to Korsmeyer-Peppas model suggesting non-Fickian behavior. Taste masking was evaluated using a five-point scale of taste evaluation. Taste of the drug was significantly concealed (p<0.05). F3 showed excellent taste concealing and considered as the most palatable formulation. In conclusion, formulated microparticles of levofloxacin could increase patient compliance and palatability. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| 9 (RLIN) |
4639 |
| Topical term or geographic name entry element |
PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| 9 (RLIN) |
11445 |
| Co-Author |
Latif, Sumera |
| 773 0# - HOST ITEM ENTRY |
|---|
| Title |
Indian journal of pharmaceutical sciences |
| Place, publisher, and date of publication |
New Delhi Indian Pharmaceutical Association |
| International Standard Serial Number |
0250-474X |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
|---|
| URL |
http://www.ijpsonline.com/articles/taste-masking-of-levofloxacin-by-microparticulate-system-using-emulsion-solvent-evaporation-technique-3698.html |
| Link text |
Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
|
| Koha item type |
Articles Abstract Database |
