| 000 -LEADER |
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| fixed length control field |
a |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20200109123739.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
200109b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
AIKTC-KRRC |
| Transcribing agency |
AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME |
|---|
| 9 (RLIN) |
11608 |
| Author |
Bhanumathi, D. N. C. |
| 245 ## - TITLE STATEMENT |
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| Title |
Correlation between pharmacokinetic properties and 15n-NMR and 13c-NMR chemicla shifts of angiotensin converting enzyme inhibitors |
| 250 ## - EDITION STATEMENT |
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| Volume, Issue number |
Vol.56(10), Oct |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Mumbai |
| Name of publisher, distributor, etc. |
Indian Drug Manufacture's Association - IDMA |
| Year |
2019 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Pagination |
26-32p. |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc. |
In the current study, angiotensin converting enzyme inhibitor molecules (enalapril, perindopril, ramipril and benazepril) were studied using 15N-nuclear magnetic resonance techniques like insensitive nuclei enhanced by polarization technique and heteronuclear multiple bond correlation. the chemical shift data and different pharmacokinetic and physicochemical properties of the molecules like pKa, half-life, time taken to reach maximum concentration in vivo, were compared and found to exhibit a good linear relationship. Further, a similar comparative study of the same parameters was performed using 13c chemical shifts of the molecules. Molecular docking studies were also performed to understand the structure of the enzyme bound to the ligand. this is perhaps the first report of 15N-nuclear magnetic resonance studies of the molecules as well as studies correlating the relationships between 15N chemical shifts, pharmacokinetics and physicochemical properties in molecules which could be used for the prediction of properties for which experimental data is currently not available. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| 9 (RLIN) |
4639 |
| Topical term or geographic name entry element |
PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| 9 (RLIN) |
11609 |
| Co-Author |
Rao, N. S. |
| 773 0# - HOST ITEM ENTRY |
|---|
| Place, publisher, and date of publication |
Mumbai Indian Drug Manufactures Association |
| Title |
Indian drugs |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
|---|
| URL |
http://www.indiandrugsonline.org/issuesarticle-details?id=OTg2 |
| Link text |
Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
|
| Koha item type |
Articles Abstract Database |
