000 -LEADER |
fixed length control field |
a |
003 - CONTROL NUMBER IDENTIFIER |
control field |
OSt |
005 - DATE AND TIME OF LATEST TRANSACTION |
control field |
20200110094348.0 |
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
fixed length control field |
200110b xxu||||| |||| 00| 0 eng d |
040 ## - CATALOGING SOURCE |
Original cataloging agency |
AIKTC-KRRC |
Transcribing agency |
AIKTC-KRRC |
100 ## - MAIN ENTRY--PERSONAL NAME |
9 (RLIN) |
11626 |
Author |
Bhagwanrao, P. V. |
245 ## - TITLE STATEMENT |
Title |
Synthesis and biological evaluation of 2-phenylpyrido[2,3-D] pyrimidine derivatives as cyclin-dependent kinase H(CDK) inhibitors |
250 ## - EDITION STATEMENT |
Volume, Issue number |
Vol.56(5), May |
260 ## - PUBLICATION, DISTRIBUTION, ETC. |
Place of publication, distribution, etc. |
Mumbai |
Name of publisher, distributor, etc. |
Indian Drug Manufacture's Association - IDMA |
Year |
2019 |
300 ## - PHYSICAL DESCRIPTION |
Pagination |
50-58p. |
520 ## - SUMMARY, ETC. |
Summary, etc. |
We report a novel scaffold of 2-phenylpyrido[2,3-d]pyrimidine derivatives designed as structural analogues of dinaciclib. Sixteen derivatives were synthesised and evaluated for their CDK2/5 inhibition activity. Compounds 4-(2-(3-methoxybenzylidene)hydrazineyl)-2-phenylpyrido[2,3-d]pyrimidine (7i) and 4-(2-(3-nitrobenzylidene)hydrazineyl)-2-phenylpyrido[2,3-d]pyrimidine (7n) show promising IC50 and kinase selectivity. These compounds also show moderate anti-proliferative activity in the colon cancer HCT116 and breast cancer MCF7 cell lines. In molecular docking studies with CDK2, compounds 7i and 7nshow binding similar to dinaciclib. |
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
9 (RLIN) |
4639 |
Topical term or geographic name entry element |
PHARMACEUTICS |
700 ## - ADDED ENTRY--PERSONAL NAME |
9 (RLIN) |
11627 |
Co-Author |
Ingole, P. G. |
773 0# - HOST ITEM ENTRY |
Title |
Indian drugs |
Place, publisher, and date of publication |
Mumbai Indian Drug Manufactures Association |
856 ## - ELECTRONIC LOCATION AND ACCESS |
URL |
https://www.indiandrugsonline.org/issuesarticle-details?id=OTMx |
Link text |
Click here |
942 ## - ADDED ENTRY ELEMENTS (KOHA) |
Source of classification or shelving scheme |
|
Koha item type |
Articles Abstract Database |