Membrane Stabilization assay for Anti-inflammatory activity yields misleading results for samples containing traces of Methanol (Record no. 10888)

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control field 20200113114355.0
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040 ## - CATALOGING SOURCE
Original cataloging agency AIKTC-KRRC
Transcribing agency AIKTC-KRRC
100 ## - MAIN ENTRY--PERSONAL NAME
9 (RLIN) 11658
Author Navale, Govind
245 ## - TITLE STATEMENT
Title Membrane Stabilization assay for Anti-inflammatory activity yields misleading results for samples containing traces of Methanol
250 ## - EDITION STATEMENT
Volume, Issue number Vol.9(3), Jul-Sep
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Place of publication, distribution, etc. Raipur
Name of publisher, distributor, etc. Asian Pharma Press
Year 2019
300 ## - PHYSICAL DESCRIPTION
Pagination 169-171p.
520 ## - SUMMARY, ETC.
Summary, etc. There is an increased in the reports on erythrocyte haemolysis assay being used as a simple and rapid tool for screening of drugs and phytochemicals for anti-inflammatory activity. However, in case of hydroalchoholic extracts, there is a possibility of the trace amounts of methanol retained even after drying. These traces are not acconted in the assay units. The present study was designated to substantiate the effects of low concentrations of methanol on the heat induced haemolysis. It was observed that the presence of methanol at concentrations as low as 0.1 ?l/ml exert significant membrane stabilizing activity. Thus, this assay may give misleading results if the test drug solution contains even slighest amount of methanol. Therefore, Present study suggested that the heat-induced erythrocyte haemolysis assay is not suitable for testing membrane stabilizing and anti-inflammmatory activity of the test samples containing methanol.
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM
9 (RLIN) 4639
Topical term or geographic name entry element PHARMACEUTICS
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9 (RLIN) 11659
Co-Author Patil, Dipak D.
773 0# - HOST ITEM ENTRY
Title Asian journal of pharmaceutical research
International Standard Serial Number 2231-5683
Place, publisher, and date of publication Raipur Asian Pharma Press
856 ## - ELECTRONIC LOCATION AND ACCESS
URL https://asianjpr.com/AbstractView.aspx?PID=2019-9-3-5
Link text Click here
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Koha item type Articles Abstract Database
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Withdrawn status Lost status Source of classification or shelving scheme Damaged status Not for loan Permanent Location Current Location Shelving location Date acquired Barcode Date last seen Price effective from Koha item type
          School of Pharmacy School of Pharmacy Archieval Section 2020-01-13 2020671 2020-01-13 2020-01-13 Articles Abstract Database
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