QUANTITATIVE ANALYSIS OF PAMABROM AND IBUPROFEN IN SYNTHETIC MIXTURE USING 1 ST ORDER DERIVATIVE SPECTROSCOPY (Record no. 11119)

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005 - DATE AND TIME OF LATEST TRANSACTION
control field 20200207155647.0
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fixed length control field 200207b xxu||||| |||| 00| 0 eng d
040 ## - CATALOGING SOURCE
Original cataloging agency AIKTC-KRRC
Transcribing agency AIKTC-KRRC
100 ## - MAIN ENTRY--PERSONAL NAME
9 (RLIN) 12017
Author Patel, Pinak
245 ## - TITLE STATEMENT
Title QUANTITATIVE ANALYSIS OF PAMABROM AND IBUPROFEN IN SYNTHETIC MIXTURE USING 1 ST ORDER DERIVATIVE SPECTROSCOPY
250 ## - EDITION STATEMENT
Volume, Issue number Vol.11(10)
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Place of publication, distribution, etc. M P
Name of publisher, distributor, etc. Innovare Academic Sciences Pvt Ltd
Year 2019
300 ## - PHYSICAL DESCRIPTION
Pagination 26-32p.
520 ## - SUMMARY, ETC.
Summary, etc. Objective:
The preliminary goal was to develop and validate 1
st
order derivative spectroscopic method for quantita
tive analysis of Pamabrom
(PAMA) which is a xanthine diuretic and ibuprofen (
IBU) which is a non-steroidal anti-inflammatory age
nt from its synthetic mixture.
Methods:
Analytical method was developed on Shimadzu double
beam spectrophotometer equipped with UV probe 2.42
as software using
methanol as solvent. Quantification of PAMA was car
ried out at zero cross over point of IBU that is 29
1 nm and for IBU, it was achieved at 278 nm
which is zero cross over point of PAMA. Method was
validated according to ICH Q2 R1 guidelines.
Results:
Method showed a linear response in the range of 2-1
2 μg/ml of PAMA and 20-120 μg/ml of IBU. Method was
found to be accurate with recovery
between 99.7–100.9 % for PAMA and 100.3–100.7 % for
IBU. The method was found to be accurate and preci
se for quantitative analysis of PAMA and IBU.
Conclusion:
The developed method was successfully validated as
per ICH Q2 R1 guidelines and was successfully appli
ed for quantitative analysis of
a synthetic mixture of PAMA and IBU.
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM
9 (RLIN) 4639
Topical term or geographic name entry element PHARMACEUTICS
700 ## - ADDED ENTRY--PERSONAL NAME
9 (RLIN) 12018
Co-Author Vasani, Priyanka
773 0# - HOST ITEM ENTRY
International Standard Serial Number 2656-0097
Title International journal of pharmacy and pharmaceutical science
Place, publisher, and date of publication Bhopal Innovare Academic Sciences Pvt Ltd
856 ## - ELECTRONIC LOCATION AND ACCESS
URL https://innovareacademics.in/journals/index.php/ijpps/article/view/34797/20904
Link text Click here
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Source of classification or shelving scheme
Koha item type Articles Abstract Database
Holdings
Withdrawn status Lost status Source of classification or shelving scheme Damaged status Not for loan Permanent Location Current Location Shelving location Date acquired Barcode Date last seen Price effective from Koha item type
          School of Pharmacy School of Pharmacy Archieval Section 2020-02-07 2020861 2020-02-07 2020-02-07 Articles Abstract Database
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