EFFECT OF LOVASTATIN NANO DRUG DELIVERY SYSTEM ON B ONE MINERAL DENSITY (BMD) AND BIOMECHANICAL PROPERTIES OF TIBIA BONES O F WISTAR RATS (Record no. 11132)
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| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20200210103740.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 200210b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 12041 |
| Author | Kaur, Ramandeep |
| 245 ## - TITLE STATEMENT | |
| Title | EFFECT OF LOVASTATIN NANO DRUG DELIVERY SYSTEM ON B ONE MINERAL DENSITY (BMD) AND BIOMECHANICAL PROPERTIES OF TIBIA BONES O F WISTAR RATS |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.11(9) |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | M P |
| Name of publisher, distributor, etc. | Innovare Academic Sciences Pvt Ltd |
| Year | 2019 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 42-48p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Objective: In the present study, transdermal nanoemulsion (NE) gel of lovastatin was investigated for its anti-os teoporosis effect on the long bones of rat i.e. tibia. Methods: Male wistar rats (n=30, weighing 180-200g) were tak en for this study and grouped as: 1) control (norma l saline daily), 2) Dex (dexamethasone sodium; 25 mg/kg subcutaneously twic e a week), 3) Dex+LNG5 (lovastatin nanoemulsion gel ; 5 mg/kg/d transdermally daily), 4) Dex+LNG10 (lovastatin nanoemulsion gel; 10 mg/kg/d transdermally daily), and 5) Dex+ALN (alendronate s odium; 0.03 mg/kg/d orally daily). All the treatments were carried out for 60 d. At the en d of the experiment, all animals were anesthetized using diethyl ether and collected blood samples from retro-orbital venous plexus of rats in dry eppendorf tubes followed by the sacrifice of a nimals by cervical dislocation method and collected tibia bones of both the legs for analysis . Results: Bone formation biomarkers (OC: osteocalcin, b-ALP: bone-specific alkaline phosphatase, PINP: N-termina l propeptides of type I procollagen) were significantly improved and resorption biomarke rs (CTx: C-terminal cross-linking telopeptides of t ype-I collagen, TRAcP5b: isoform 5b of tartarate resistant acid phosphatase) were significantly redu ced in the LNG5 (p<0.05) and LNG10 (p<0.05) treatme nt groups when compared to Dex. In vivo anti- osteoporotic results demonstrated the formation of new bone in osteoporotic rat tibias. Biomechanical strength testing demonstrated increased load- bearing capacity of rat tibias in the treated anima ls in comparison with the osteoporotic group (p<0.0 5 for LNG5 and p<0.01 for LNG10). |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 9738 |
| Co-Author | Ajitha, Makula |
| 773 0# - HOST ITEM ENTRY | |
| Place, publisher, and date of publication | Bhopal Innovare Academic Sciences Pvt Ltd |
| Title | International journal of pharmacy and pharmaceutical science |
| International Standard Serial Number | 2656-0097 |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://innovareacademics.in/journals/index.php/ijpps/article/view/34624/20639 |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Permanent Location | Current Location | Shelving location | Date acquired | Barcode | Date last seen | Price effective from | Koha item type |
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| School of Pharmacy | School of Pharmacy | Archieval Section | 2020-02-10 | 2020872 | 2020-02-10 | 2020-02-10 | Articles Abstract Database |