SYNTHESIS AND UTILITY OF NEW POLYCYCLIC COMPOUNDS A S POTENTIAL ANTIMICROBIALS BASED ON CHROMENE MOIETY (Record no. 11133)
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| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20200210104338.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 200210b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 12042 |
| Author | Abdelaziz, Mahmoud N. |
| 245 ## - TITLE STATEMENT | |
| Title | SYNTHESIS AND UTILITY OF NEW POLYCYCLIC COMPOUNDS A S POTENTIAL ANTIMICROBIALS BASED ON CHROMENE MOIETY |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.11(9) |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | M P |
| Name of publisher, distributor, etc. | Innovare Academic Sciences Pvt Ltd |
| Year | 2019 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 49-56p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Objective: The present research aims to synthesize some new po lycyclic compounds including chromene moiety and st udy their antimicrobial activity. Methods: Several new polycyclic systems including chromene s caffold incorporated with pyridine, pyrimidine, imi dazopyrimidine, and imidazodiazocine were achieved via condensation reaction of chromene derivative under the proper condition with various reagents namely; cyanothioacetamide, phenyl isothiocyanate, malononi trile, carbon disulfide, benzaldehyde, triethylorth oformate, and 1,4-dichlorobutane. Moreover, a chlorodiazenyl chromene derivative was reacted wi th some substances possessing active–CH 2 -bridge such as ethyl cyanoacetate and malononitrile to end up with hydrazono compounds. S uch compounds were eventually cyclized with hydrazi ne hydrate to form pyrazole and oxopyrazole derivatives. Moreover, compound 1 was treated with benzoyl acetone, and then followed by cyclization with malononitrile to provide the corresponding 2-amino14-(4-methoxyphenyl)-4-met hy-5-phenyl-14H-benzo[5,6] chromeno [2,3H][1,6]napht hyridine-3-carbonitrile (20). Results: The results of the antimicrobial screening in vitro revealed that the inhibition zone (mm) of the synt hesized compounds 1-3, 5 and 8 implied their optimum antibacterial activity, while the compounds 4, 6 and 9-13, 15 showed a moderate to weak antibacterial activity against multiple species of B. subtilis, S. aureus, E. coli and P. aeruginosa . In contrast, the compounds 1, 6, 11, 15 showed hi gh antifungal activities against different species of A. flavinand C. albicans , while the other compounds exhibit a moderate to p oor antifungal activity. Conclusion: It is remarkable that a series of chromene derivati ves synthesized by a simple and available method le ads to a molecule of promising antimicrobial activity. Further research is recomme nded to approve the importance of polycyclic system s for various applications. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 12043 |
| Co-Author | Zarie, Eman S. |
| 773 0# - HOST ITEM ENTRY | |
| Title | International journal of pharmacy and pharmaceutical science |
| International Standard Serial Number | 2656-0097 |
| Place, publisher, and date of publication | Bhopal Innovare Academic Sciences Pvt Ltd |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://innovareacademics.in/journals/index.php/ijpps/article/view/34338/20640 |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Permanent Location | Current Location | Shelving location | Date acquired | Barcode | Date last seen | Price effective from | Koha item type |
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| School of Pharmacy | School of Pharmacy | Archieval Section | 2020-02-10 | 2020873 | 2020-02-10 | 2020-02-10 | Articles Abstract Database |