ENHANCEMENT OF COLLAGEN SYNTHESIS PROCESS ON DIABETIC WOUND BY MERREMIA MAMMOSA ( LOUR .) EXTRACT FRACTI ON (Record no. 11153)
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| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20200211094123.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 200211b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 12072 |
| Author | Marchianti, Ancah Caesarina Novi |
| 245 ## - TITLE STATEMENT | |
| Title | ENHANCEMENT OF COLLAGEN SYNTHESIS PROCESS ON DIABETIC WOUND BY MERREMIA MAMMOSA ( LOUR .) EXTRACT FRACTI ON |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.11(2) |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | M P |
| Name of publisher, distributor, etc. | Innovare Academic Sciences Pvt Ltd |
| Year | 2019 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 47-50p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Objective: This research aimed to evaluate the effect of fracti onation of Merremia mammosa Lour . ( Mm (Lour.) ) extract on diabetic wound healing by observing the collagen synthesis process and to search the most potent fraction . Method s: Wistar rats were divided into five groups (n=5), i.e., K-(negative control ), K+(positive control ), K1 (ethyl acetate fraction), K 2 (water fraction), and K3 (n -hexane fraction). The Mm (Lour.) was extracted with ethanol 70% , then fractio nated by using three solvents which have different polarity. The rats were adapted in 7 d , then induced into diabetic by streptozotocin dose 4 0 mg /kg body weight. The wound wa s made by Morton ex cision method. Treatment was given every two days and a skin biopsy was done on day 11. Analysis of collagen density wa s done by photomicrograph of histopathology preparations in Masson’s trichome stained by using trinocular microscope w ith 400x magnification in 6 fields of view , then processed by imageJ software and analyzed by appropriate statistic tool . Result s: The results of this research showed that fracti onation of Mm (Lour.) extract significant ly enhance d diabetic wound healing based on macroscopic (percentage of wound healing) and collagen density with p -valu e<0.05 when compared with negative control , especially the water fraction (p=0.00 0). The follow -up post hoc analysis showed that there was no significant (p =0.989 ) or there was no meaningful difference in the group of water fraction when compared to posit ive control. Conclusio n: Water fraction is the extract fraction of Mm (Lour.) which has the most significant influence on diabetic wound healing showed by enhancement of collagen synthesis. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 12073 |
| Co-Author | Prameswari, Mega Citra |
| 773 0# - HOST ITEM ENTRY | |
| Place, publisher, and date of publication | Bhopal Innovare Academic Sciences Pvt Ltd |
| International Standard Serial Number | 2656-0097 |
| Title | International journal of pharmacy and pharmaceutical science |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://innovareacademics.in/journals/index.php/ijpps/article/view/30170/19153 |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Permanent Location | Current Location | Shelving location | Date acquired | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| School of Pharmacy | School of Pharmacy | Archieval Section | 2020-02-11 | 2020887 | 2020-02-11 | 2020-02-11 | Articles Abstract Database |