ALUMINA CATALYST: SYNTHESIS OF NOVEL QUINAZOLINE DE RIVATIVES AND THEIR SOLUBILITY INCREASES THROUGH INCLUSION WITH β-CYCLO DEXTRIN (Record no. 11154)
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| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20200211094619.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 200211b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 12074 |
| Author | Hossain, Mossaraf |
| 245 ## - TITLE STATEMENT | |
| Title | ALUMINA CATALYST: SYNTHESIS OF NOVEL QUINAZOLINE DE RIVATIVES AND THEIR SOLUBILITY INCREASES THROUGH INCLUSION WITH β-CYCLO DEXTRIN |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.11(2) |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | M P |
| Name of publisher, distributor, etc. | Innovare Academic Sciences Pvt Ltd |
| Year | 2019 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 51-58p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Objective: To synthesis a novel methodology of bioactive quina zoline derivatives under greener process to an exce llent yields and increases their solubility via inclusion with β-cyclodextrin (CD). Methods: Derivatives of quinazoline compounds were prepared by the mixture of 3-amino-2-phenylquinazolin-4(3H)- one, derived from 2-phenyl- 4H-benzo[1,3]oxazin-4-one by refluxing with hydrazi ne, substituted aromatic aldehyde and alumina intim ately in an agate mortar and pestle under solvent-free condition. Using various techniques fo r preparing inclusion complexes, kneaded method is the best method for encapsulation in host- guest complex chemistry. All compounds including in clusion complexes were characterised by spectral me thods. Results: Synthesized a series of novel quinazoline compounds under a very easier greener process with a commerc ially available reagent. However, their low bioavailability, due to low absorption an d solubility, can limit their potential application s. CD was used to resolve this solubility problem. CD can easily accommodated the guest molecules to e ncapsulate inside its cavity due to interior the hy drophobic nature with a hydrophilic exterior part to form thermodynamically more stable molecula r microcapsules, commonly name as host-guest comple xes or inclusion complexes. In this sense, CD was utilized to enhance not only the solu bility and bioavailability of these quinazoline com pounds but also their antibacterial capacity. The formation of inclusion complex was thus confirm ed by ultraviolet-visible spectroscopy (UV-VIS), Fo urier Transform Infrared Spectrometry (FT- IR), differential scanning calorimetry (DSC) and so lubility study technique. Conclusion: Here we have successfully unfolded an eco-friendly methodology for the synthesis of derivatives of qui nazoline and increased their solubility via host-guest inclusion technique. From the spectral analysis, it was concluded that the q uinazoline compound is fully encapsulated inside the cavity of the CD. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 12075 |
| Co-Author | Nanda, Ashish Kumar |
| 773 0# - HOST ITEM ENTRY | |
| Place, publisher, and date of publication | Bhopal Innovare Academic Sciences Pvt Ltd |
| Title | International journal of pharmacy and pharmaceutical science |
| International Standard Serial Number | 2656-0097 |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://innovareacademics.in/journals/index.php/ijpps/article/view/30338/19154 |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Permanent Location | Current Location | Shelving location | Date acquired | Barcode | Date last seen | Price effective from | Koha item type |
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| School of Pharmacy | School of Pharmacy | Archieval Section | 2020-02-11 | 2020888 | 2020-02-11 | 2020-02-11 | Articles Abstract Database |