DEVELOPMENT AND IN VITRO EVALUATION OF A NEW TOPICAL O/W EMULGEL FROM FRUIT EXTRACT OF PYRUS COMMUNIS (Record no. 11179)
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| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20200212101008.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 200212b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 12120 |
| Author | Khiljee, Tanzila |
| 245 ## - TITLE STATEMENT | |
| Title | DEVELOPMENT AND IN VITRO EVALUATION OF A NEW TOPICAL O/W EMULGEL FROM FRUIT EXTRACT OF PYRUS COMMUNIS |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.11(4) |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | M P |
| Name of publisher, distributor, etc. | Innovare Academic Sciences Pvt Ltd |
| Year | 2019 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 75-79p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Objective : The aim of the present study was to develop a new t opical dosage form containing Pyrus communis fruit extract. Developed formulation was O/W Emulgel which was evaluated by its in vitro tests and its stability studies at different stora ge conditions. Methods : Hydroalcoholic Pyrus communis extract was prepared by the maceration process. A 4% Pyrus communis emulgel was prepared by the combination of emulsion and gel at a specific tempe rature and mixing through homogenizers. The formula tions having different concentration of carbopol 940 (gelling agent) were placed at 8 °C, 2 5 °C, 40 °C and 40 °C+75%RH for 3 mo in order to fi nd out the most stable formulation. After the selection of final emulgel formulation was eventual ly further evaluated for in vitro studies such as phase separation, centrifugation, rheology, pH, conductivity, organoleptic properties and mean drop let size over a period of 12 w at 8 °C, 25 °C, 40 ° C and 40 °C+75%RH. Results : In vitro evaluation of the selected Pyrus communis emulgel formulation showed good resistance to phas e separation on centrifugation, conductivity gradually increases due to oil in wate r emulgel and pH of formulation was gradually decre ased. The rheological behavior was non- Newtonian pseudoplastic and showed shear thinning f luid behavior. Mean droplet size of Pyrus communis emulgel was 16.0±0.20 μm and after 90 d droplet size was 16.7±0.55 μm at high storage tempe ratures at 40 °C and 40 °C+75RH and no significant c hanges were observed at normal storage conditions at 8 °C and 25 °C. Conclusion : Pyrus communis emulgel fresh fruit extract showed stable formulat ion at different storage conditions. This new formu lation will be a good addition to pharmaceutical dosage forms made f rom traditionally used plants. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 12121 |
| Co-Author | Naveed Akhtar |
| 773 0# - HOST ITEM ENTRY | |
| International Standard Serial Number | 2656-0097 |
| Title | International journal of pharmacy and pharmaceutical science |
| Place, publisher, and date of publication | Bhopal Innovare Academic Sciences Pvt Ltd |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://innovareacademics.in/journals/index.php/ijpps/article/view/29063/19672 |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Permanent Location | Current Location | Shelving location | Date acquired | Barcode | Date last seen | Price effective from | Koha item type |
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| School of Pharmacy | School of Pharmacy | Archieval Section | 2020-02-12 | 2020912 | 2020-02-12 | 2020-02-12 | Articles Abstract Database |