NEPHROPROTECTIVE ACTIVITY OF PLUMERIA RUBRA AGAINST CISPLATIN INDUCED NEPH ROTOXICITY IN EXPERIMENTAL RATS (Record no. 11185)
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| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20200212104053.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 200212b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 3641 |
| Author | Yadav, A. V. |
| 245 ## - TITLE STATEMENT | |
| Title | NEPHROPROTECTIVE ACTIVITY OF PLUMERIA RUBRA AGAINST CISPLATIN INDUCED NEPH ROTOXICITY IN EXPERIMENTAL RATS |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.11(4) |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | M P |
| Name of publisher, distributor, etc. | Innovare Academic Sciences Pvt Ltd |
| Year | 2019 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 108-113p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Objective: The current study was designed to evaluate the pro tective effect of standardized hydroalcoholic extra ct of Plumeria rubra (HAEPR) against cisplatin-induced nephrotoxicity in Wistar rats. Methods: HAEPR was administered orally at 3 dose levels (100 ,200,400 mg/kg). Vitamin E (250 mg/kg) was used as a Standard nephroprotective agent. The kidney function test (estimation of seru m creatinine, albumin, blood urea nitrogen) oxidati ve stress study (estimation of superoxide dismutase, malondialdehyde activity) and histologic al examination of kidneys was conducted. Results: The efficacy of HAEPR was compared with Cisplatin ( CP) treated group. Serum creatinine and BUN was sig nificantly (p<0.01) elevated in CP-treated group compared to the control group. HAE PR (100,200 mg/kg) and Vitamin E (250 mg/kg) signif icantly (p<0.01) decreased the serum creatinine and BUN levels. CP treated group exhibit ed significant (p<0.01) decrease in albumin when co mpared to control. Significant (p<0.01) increase in the serum albumin level was found in HAE PR (100,200 mg/kg) and Vitamin E (250 mg/kg) compar ed to CP group. Significant (p<0.01) decrease in the activity of SOD was observed in the CP group as compared to control. HAEPR (100 and 20 0 mg/kg) and Vitamin E (250 mg/kg) significantly (p<0.01) increased SOD levels. HAEPR ( 400 mg/kg) significantly (p<0.05) increased SOD lev els. HAEPR (100,200,400 mg/kg) significantly (p<0.01) decreased MDA levels as comp ared to CP group. Histopathological examination of t he kidneys showed that HAEPR markedly ameliorated Cisplatin-induced renal tubular necrosi s. An extract was found effective at all doses, alt hough low dose (100 mg/kg) was found to be more effective and comparable with the standard gro up (Vitamin E 250 mg/kg). |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 12132 |
| Co-Author | Upasani, C. D. |
| 773 0# - HOST ITEM ENTRY | |
| Place, publisher, and date of publication | Bhopal Innovare Academic Sciences Pvt Ltd |
| International Standard Serial Number | 2656-0097 |
| Title | International journal of pharmacy and pharmaceutical science |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://innovareacademics.in/journals/index.php/ijpps/article/view/31561/19678 |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Permanent Location | Current Location | Shelving location | Date acquired | Barcode | Date last seen | Price effective from | Koha item type |
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| School of Pharmacy | School of Pharmacy | Archieval Section | 2020-02-12 | 2020918 | 2020-02-12 | 2020-02-12 | Articles Abstract Database |