IMPROVEMENT OF BETULIN-3, 28-DIPHOSPHATE WATER- SOLUBILITY BY COMPLEXATION WITH AMINES–MEGLUMINE AND XYMEDON (Record no. 11194)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20200212134542.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 200212b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 12148 |
| Author | Melnikova, Nina |
| 245 ## - TITLE STATEMENT | |
| Title | IMPROVEMENT OF BETULIN-3, 28-DIPHOSPHATE WATER- SOLUBILITY BY COMPLEXATION WITH AMINES–MEGLUMINE AND XYMEDON |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.11(5) |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | M P |
| Name of publisher, distributor, etc. | Innovare Academic Sciences Pvt Ltd |
| Year | 2019 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 48-55p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Objective: To study betulin-3,28-diphosphate (BDP) water solub ility improved by forming salt complexes with hydro philic amino alcohols: meglumine as acidosis corrector and xymedon as the water-soluble antioxidant. Methods: We used 13 C-, 31 P-NMR, UV-spectroscopy and potentiometric titration to study the BDP-amine salt complexes formation an d their solubility using HPLC-analysis. Results: The participation of xymedon in the proton transfer reaction with BDP in aqueous solutions was confirm ed by the bathochromic shift of the carbonyl band from 299.1 nm to 304.2 nm, and by a hyperchromic effect (molar extinction ε from 850 8 to 10 441 l·mol -1 ·cm -1 ) in UV-spectra. BDP complexation with meglumine was estimated by UV -spectral molar ratio method at 256 nm. Molar ratio of BDP-amine complexes (1:4) was proved by 31 P-NMR. The chemical shift of phosphorus at C-3 atom of BDP (δ =-0.58 ppm) changed to+3.39 ppm, and at C-28 atom (δ =+0.28 ppm)– to+4.60 ppm. BDP solubility increased 100-600 fold according to HPLC-analysis. Conclusion: BDP interaction with amine in an aqueous solution w as shown to proceed via a proton transfer due to re latively weak forces such as London forces, hydrogen bonding, electrostatic and hydrophobic interactions. In general, the formation of BDP salt complexes with amines in solution determines BDP water solubility. Water-sol uble BDP enables to develop hydrophilic dosage form s. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 12149 |
| Co-Author | Malygina, Darina |
| 773 0# - HOST ITEM ENTRY | |
| International Standard Serial Number | 2656-0097 |
| Title | International journal of pharmacy and pharmaceutical science |
| Place, publisher, and date of publication | Bhopal Innovare Academic Sciences Pvt Ltd |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://innovareacademics.in/journals/index.php/ijpps/article/view/32707/19864 |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Permanent Location | Current Location | Shelving location | Date acquired | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| School of Pharmacy | School of Pharmacy | Archieval Section | 2020-02-12 | 2020927 | 2020-02-12 | 2020-02-12 | Articles Abstract Database |