CHARACTERIZATION , IN VITRO ANTIOXIDANT AND HEPATOPROTECTIVE ACTIVITY OF FUNGAL ENDOPHYTIC EXTRACTS OF ANDROGRAPHIS PANICULATA LEAVES IN CCL Original Article 4 INDUCED HEPATOTOXICITY (Record no. 11202)
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| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20200213102043.0 |
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| fixed length control field | 200213b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 12163 |
| Author | Puri, Smita K. |
| 245 ## - TITLE STATEMENT | |
| Title | CHARACTERIZATION , IN VITRO ANTIOXIDANT AND HEPATOPROTECTIVE ACTIVITY OF FUNGAL ENDOPHYTIC EXTRACTS OF ANDROGRAPHIS PANICULATA LEAVES IN CCL Original Article 4 INDUCED HEPATOTOXICITY |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.11(1) |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | M P |
| Name of publisher, distributor, etc. | Innovare Academic Sciences Pvt Ltd |
| Year | 2019 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 44-54p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Objective: To isolate and characterize the endophytic fungi from the leaves of Andrographis paniculata for free radical scavenging antioxidant and hepatopr otective activity against CCl 4 Method s: Two fungal endophytes, APLF -3 ( Andrographis paniculata leaf fungi -3) and APLF -4 ( Andrographis paniculata leaf fungi -4) were isolated from leaves of Andrographis paniculata to get chloroform (A3C, A4C), ethyl acetate (A3EA, A4EA) and n butanol (A3nB, A4nB) extracts. rDNA sequencing by PCR technique was carried out for identification of APLF -3 and APLF -4. All the APLF -3 and APLF -4 extracts were assayed for in vitro free radical scavenging activity against 2, 2 -diphenyl -1-picrylhydrazyl (DPPH), hydroxyl radical and redu cing power. Then, A4EA and A4nB were screened for hepatoprotective activity against CCl induced hepatotoxicity 4 Result s: The endophytic fungi, APLF -3 and APLF -4, were identified as Phyllosticta sp. ZLY -2010 isolate M13 and Aspergillus tubingensis strain Cs/7/2 respectively based on their morphological and molecular characterization. A4EA and A4nB showed significant in vitro free radical scavenging activity as compared to other extracts. A4EA and A4nB (50 mg/kg and 100 mg/kg) reversed the increased serum biochemical parameters as compared to CCl induced hepatotoxicity at 50 mg/kg and 100 mg/kg doses. 4 Conclusio n: These findings suggested that the extracts (A4EA and A4nB) obtained from endophytic fungi APLF -4 contributed towards hepatoprotective activity. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 12164 |
| Co-Author | Habbu, Prasanna V. |
| 773 0# - HOST ITEM ENTRY | |
| International Standard Serial Number | 2656-0097 |
| Place, publisher, and date of publication | Bhopal Innovare Academic Sciences Pvt Ltd |
| Title | International journal of pharmacy and pharmaceutical science |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://innovareacademics.in/journals/index.php/ijpps/article/view/26832/16538 |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Permanent Location | Current Location | Shelving location | Date acquired | Barcode | Date last seen | Price effective from | Koha item type |
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| School of Pharmacy | School of Pharmacy | Archieval Section | 2020-02-13 | 2020935 | 2020-02-13 | 2020-02-13 | Articles Abstract Database |