ESTIMATION OF PHARMACOKINETIC PARAMETERS AND ACCURACY OF THE PREDICTED EQUATION FOR LITHIUM DOSE IN CHILDRE N: A PILOT STUDY AT THE YUWAPRASART WAITHAYOPATHUM CHILD PSYCHIATRIC HOSPITAL (Record no. 11209)
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| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20200213113824.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 200213b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 10064 |
| Author | Tewthanom, Karunrat |
| 245 ## - TITLE STATEMENT | |
| Title | ESTIMATION OF PHARMACOKINETIC PARAMETERS AND ACCURACY OF THE PREDICTED EQUATION FOR LITHIUM DOSE IN CHILDRE N: A PILOT STUDY AT THE YUWAPRASART WAITHAYOPATHUM CHILD PSYCHIATRIC HOSPITAL |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.11(1) |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | M P |
| Name of publisher, distributor, etc. | Innovare Academic Sciences Pvt Ltd |
| Year | 2019 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 72-78p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Objective : The purpose of the study was to estimate the pharmacokinetic parameters and calculate the prec ision (%RMSE) of the predicted l ithium concentration equation. Method s : This research was studied from blood Lithium levels of Children who had visited Yuwaprasa rt Waithayopathum Child Psychia tric Hospital from 31 December 2009 -1 January 2011 The accuracy and precision of the equation were evaluated by the mathematical principle. The assist package software (WIN -NONLIN) was used to create pharmacokinetic parameters. Result s : Twenty -nine patien ts were recruited. The characteristics (mean +SD) presented as the followin g; age = 15.79 +2.6 4 y , weight = 69.75+22.28 kg and the daily dose = 858.62+ 274.53 mg. The trough Lithium concentrations (mean +SD) = 0.56+ 19 mg/l . The kinetic parameter (Mean +SD) pres ented as the followin g; t 1/2 Conclusio n : In conclusion, the modified Yukawa equation may be used for the prediction of l ithium concentration with 6.39% RMSE. =7.23 +3.38 hr., ke =0.12 +0.07 hr -1, Vd = 48.83 +15.60 L, AUC0 -12 =11.01 +5.61 mg x hr /l. The population pharmacokinetic parameter s; ke, and AUC (0 - ∞) = 0.151 hr -1 and 169.81, mg x hr./l respectively. The mod ified equation from Yukawa for l ithium cleara nce calculation and prediction l ithium concentrations were CL (mL/min) = [36.5+(0.242x BW (kg) -7.79]/Scr (mg/dL) and l ithium concentration (mg /l) = 4 x Dose (mg) /CL (mL/min)x73.89, respectively with 6.39 %RMSE (test for 20 patients data). |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 12178 |
| Co-Author | Ongarjsakulman, Rinsook |
| 773 0# - HOST ITEM ENTRY | |
| Title | International journal of pharmacy and pharmaceutical science |
| International Standard Serial Number | 2656-0097 |
| Place, publisher, and date of publication | Bhopal Innovare Academic Sciences Pvt Ltd |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://innovareacademics.in/journals/index.php/ijpps/article/view/29517/16548 |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Permanent Location | Current Location | Shelving location | Date acquired | Barcode | Date last seen | Price effective from | Koha item type |
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| School of Pharmacy | School of Pharmacy | Archieval Section | 2020-02-13 | 2020939 | 2020-02-13 | 2020-02-13 | Articles Abstract Database |