FORMULATION AND OPTIMIZATION OF TERBINAFINE HCl SOLID LIPID NANOPARTICLES FOR TOPICAL ANTIFUNGAL ACTIVITY (Record no. 11251)
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| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20200214110603.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 200214b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 12256 |
| Author | Abobakr, Fatma E. |
| 245 ## - TITLE STATEMENT | |
| Title | FORMULATION AND OPTIMIZATION OF TERBINAFINE HCl SOLID LIPID NANOPARTICLES FOR TOPICAL ANTIFUNGAL ACTIVITY |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.11(12) |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | M P |
| Name of publisher, distributor, etc. | Innovare Academic Sciences Pvt Ltd |
| Year | 2019 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 16-25p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Objective: Soli d lipid nanoparticles (SLNs) are at the forefront of the rapidly developing field of nanotechnology with several potential applications in drug delivery and res earch. The aim of this study was to develop and characterize SLNs formulae of Terbinafine HCl (TFH) for topical drug delivery application s. Method s: SLNs were prepared using the solvent injection technique. Glyceryl M onostearate (GMS) served as the lipid base. Three stabilizer s; Tween 80, C remophor RH40 , and Poloxame r 188 , were used. The effect of stabilizer type and concentration , as well as the li pid concentration , were studied , factorial design of 3 2 *2 1 was applied. The prepared SLNs were characterized regarding their particle size, zeta potential, polydispersity index (PDI) , entrapment eff iciency percent (EE %) , and physicochemical stability. The selected formulae were subjected to further investigations such as morphological studies, in vitro release studies , and Infrared (IR) spectroscopy. The y were compared with the marketed cream Lamifen ® in term of their antifungal activity against Candida alb icans . Result s: Lipid concentration , together with the type and concentration of stabilizer , appeared to be the main cornerstones which affect the formation of SLNs. Smaller particle size was observed when increasing the stabilizer concentration and decrea sing the lipid concentration. Higher EE% was observed when increasing both the stabilizer and the lipid concentration s. Formulae (F6, F12 andF19) were selected as the most suitable SLNs with optimum particle size of 480.2 ±18.89, 458.6 ±12.45 and 246.7 ±10.5 nm , respectively as well as the highest EE% of 87.13 ±0.19, 93.69 ±0.7 and 95.06 ±0.25 , respectivel y. In vitro microbiological screening of their antifungal activity showed significantly larger zone s of inhibition of diameters 25.9 ±0.25, 25 ±0.35 and 24.67 ±0.3 6 mm , respectively in comparison with the marketed Lamifen® cream which showed a zone of 11.2 ±0.44 mm diameter . Conclusio n: Applying SLNs containing TFH as topic |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 12257 |
| Co-Author | Sahar, M. Fayez |
| 773 0# - HOST ITEM ENTRY | |
| Title | International journal of pharmacy and pharmaceutical science |
| Place, publisher, and date of publication | Bhopal Innovare Academic Sciences Pvt Ltd |
| International Standard Serial Number | 2656-0097 |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://innovareacademics.in/journals/index.php/ijpps/article/view/35560/21240 |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Permanent Location | Current Location | Shelving location | Date acquired | Barcode | Date last seen | Price effective from | Koha item type |
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| School of Pharmacy | School of Pharmacy | Archieval Section | 2020-02-14 | 2020966 | 2020-02-14 | 2020-02-14 | Articles Abstract Database |