| 000 -LEADER |
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| fixed length control field |
a |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20200217110200.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
200217b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
AIKTC-KRRC |
| Transcribing agency |
AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME |
|---|
| 9 (RLIN) |
12360 |
| Author |
Hong, H. L. |
| 245 ## - TITLE STATEMENT |
|---|
| Title |
Preparation, Characterization and in vitro Evaluation of Tosufloxacin Tosylate and Hydroxypropyl-β-cyclodextrin Inclusion Complex |
| 250 ## - EDITION STATEMENT |
|---|
| Volume, Issue number |
Vol.81(2), Mar-Apr |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Mumbai |
| Name of publisher, distributor, etc. |
Indian Journal of Pharmaceutical Science |
| Year |
2019 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Pagination |
249-258p. |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
The aim of this study was to increase the water solubility of tosufloxacin tosylate by inclusion with hydroxypropyl-β-cyclodextrin. The tosufloxacin tosylate/hydroxypropyl-β-cyclodextrin inclusion complex was characterized by differential scanning calorimetry, powder X-ray diffractometry, and scanning electron microscopy. Fourier-transform infrared spectroscopy, nuclear magnetic resonance and 2D rotating frame nuclear Overhauser effect spectroscopy were used to identify the interaction of tosufloxacin tosylate and hydroxypropyl-β-cyclodextrin. Results obtained confirmed the formation of tosufloxacin tosylate/hydroxypropyl-β-cyclodextrin inclusion complex. In addition, the dissolution and stability of the complex was also evaluated, which indicated that the water solubility and stability of tosufloxacin tosylate were significantly increased in the presence of hydroxypropyl-β-cyclodextrin. Furthermore, dissolution assay showed that the dissolution of tosufloxacin tosylate/hydroxypropyl-β-cyclodextrin inclusion complex was higher than that of a physical mixture or tosufloxacin tosylate alone. These results demonstrated that hydroxypropyl-β-cyclodextrin could be potentially beneficial in the delivery of water-insoluble tosufloxacin tosylate. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| 9 (RLIN) |
4639 |
| Topical term or geographic name entry element |
PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| 9 (RLIN) |
12361 |
| Co-Author |
Sun, J. F. |
| 773 0# - HOST ITEM ENTRY |
|---|
| Title |
Indian journal of pharmaceutical sciences |
| International Standard Serial Number |
0250-474X |
| Place, publisher, and date of publication |
New Delhi Indian Pharmaceutical Association |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
|---|
| URL |
https://www.ijpsonline.com/articles/preparation-characterization-and-iin-vitroi-evaluation-of-tosufloxacin-tosylate-and-hydroxypropylcyclodextrin-inclusion-.pdf |
| Link text |
Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
|
| Koha item type |
Articles Abstract Database |
