| 000 -LEADER |
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| fixed length control field |
a |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20200923160040.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
200923b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
AIKTC-KRRC |
| Transcribing agency |
AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME |
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| 9 (RLIN) |
12597 |
| Author |
Saufi, Aimi Nabila Mohamad |
| 245 ## - TITLE STATEMENT |
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| Title |
Fluorometric and Docking Analysis of the Complex Formation between an Anti-cancer Drug, Chlorambucil and Bovine Serum Albumin |
| 250 ## - EDITION STATEMENT |
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| Volume, Issue number |
Vol.53(4), Oct-Dec |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Karnataka |
| Name of publisher, distributor, etc. |
Association of Pharmaceutical Teachers of India (APTI) |
| Year |
2019 |
| 300 ## - PHYSICAL DESCRIPTION |
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| Pagination |
682-687p. |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc. |
Background: To characterize the interaction between chlorambucil (CHB) and the carrier protein, bovine serum albumin (BSA) in order to understand the transport of this drug in blood circulation. Methods: Fluorescence quenching titration method was used to examine the interaction of CHB with BSA by determining its binding constant and binding stoichiometry. The binding site identification was probed with molecular docking techniques. Results: Values of the Stern-Volmer constant (KSV), bimolecular quenching rate constant (kq)and binding constant (Ka)for CHB-BSA system were determined as 3.57×104 M−1, 5.67 × 1012 M−1 s−1 and5.58 × 104 M−1, respectively. Binding stoichiometry was found to be ~1.0, as obtained from the double logarithmic plot. The molecular docking results revealed that CHB binds to both Site I and Site II of BSA, however Site II was predicted to be the preferred binding site. Conclusion: The value of Ka suggested intermediate binding affinity between CHB and BSA with the binding stoichiometry of 1:1. CHB was found to have the binding preference at Site II of BSA due to formation of greater contacts |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| 9 (RLIN) |
4639 |
| Topical term or geographic name entry element |
PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| 9 (RLIN) |
12598 |
| Co-Author |
Nor Farrab, Wahidah Ridzwan |
| 773 0# - HOST ITEM ENTRY |
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| International Standard Serial Number |
0019-5464 |
| Title |
Indian journal of pharmaceutical education and research |
| Place, publisher, and date of publication |
Bengluru Association of Pharmaceutical Teachers of India (APTI) |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| URL |
https://www.ijper.org/sites/default/files/IndJPhaEdRes_53_4_682.pdf |
| Link text |
Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
|
| Koha item type |
Articles Abstract Database |
