| 000 -LEADER |
|---|
| fixed length control field |
a |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20201207120009.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
201207b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
AIKTC-KRRC |
| Transcribing agency |
AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME |
|---|
| 9 (RLIN) |
12705 |
| Author |
Parveena, A. |
| 245 ## - TITLE STATEMENT |
|---|
| Title |
In vitro and in silico Analysis to Identify Novel Lead Compound from Morinda tinctoria fruit Against Breast Cancers |
| 250 ## - EDITION STATEMENT |
|---|
| Volume, Issue number |
Vol.51(5), Sep-Oct |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Mumbai |
| Name of publisher, distributor, etc. |
Indian Journal of Pharmaceutical Science |
| Year |
2019 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Pagination |
970-975p. |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
In the present study, the anticancer activity of Morinda tinctoria fruit extract was evaluated in vitro and in silico. The ethanol extract of the fruit was prepared and subjected to preliminary screening and gas chromatography-mass spectrometry analysis to identify phytochemical constituents. Free radical scavenging activity of Morinda tinctoria fruit extract was evaluated using 2,2’-azinibis(3- ethylbenzothiazoline-6-sulfonic acid and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Morinda tinctoria fruit extract at 125 μg/ml concentration inhibited the growth of MDA-MB cell lines. The drug likenesses property of compounds present in the ethanol extract was analysed based on Lipinski’s rule of five. The breast cancer protein ErBb2 was chosen as target for studying the molecular interaction with selected ligands. Corynan-17-ol,18,19-didehydro-10-methoxy was selected as an efficient lead molecule against target-based on the lowest binding energy value of –5.9 Kcal/mol. This showed that the fruit of Morinda tinctoria could be explored to identify promising lead molecules against breast cancer. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| 9 (RLIN) |
4639 |
| Topical term or geographic name entry element |
PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| 9 (RLIN) |
12706 |
| Co-Author |
Arthi, S. |
| 773 0# - HOST ITEM ENTRY |
|---|
| Place, publisher, and date of publication |
New Delhi Indian Pharmaceutical Association |
| Title |
Indian journal of pharmaceutical sciences |
| International Standard Serial Number |
0250-474X |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
|---|
| URL |
https://www.ijpsonline.com/articles/iin-vitroi-and-iin-silicoi-analysis-to-identify-novel-lead-compound-from-imorinda-tinctoriai-fruit-against-breast-cancer.pdf |
| Link text |
Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
|
| Koha item type |
Articles Abstract Database |
