| 000 -LEADER |
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| fixed length control field |
a |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20201215094410.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
201215b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
AIKTC-KRRC |
| Transcribing agency |
AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME |
|---|
| 9 (RLIN) |
12758 |
| Author |
Sun, R. L. |
| 245 ## - TITLE STATEMENT |
|---|
| Title |
Nuclear Role of LOX-1 in XinMaiJia-attenuating Atherosclerosis in Rabbits |
| 250 ## - EDITION STATEMENT |
|---|
| Volume, Issue number |
Vol.81(6), Nov-Dec |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Mumbai |
| Name of publisher, distributor, etc. |
Indian Journal of Pharmaceutical Science |
| Year |
2019 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Pagination |
1020-1028p. |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
This study aimed to explore the nuclear role of lectin-like oxidised low density lipoprotein receptor-1 in atherosclerotic rabbits treated with XinMaiJia to further confirm that low density lipoprotein receptor-1 is a target of XinMaiJia in attenuating atherosclerosis. Atherosclerotic model of rabbits was established. Lovastatin, zhibituo and different concentrations of XinMaiJia were administered to atherosclerotic rabbits. Pathological examination was performed on the right common carotid artery, cytokines reflected inflammation and oxidative stress level were detected. Moreover, endothelin-1, low density lipoprotein receptor-1 and endothelial nitric oxide synthase expression were measured. XinMaiJia prevented the development of atherosclerosis and reduced low density lipoprotein receptor-1 expression in rabbits. For antioxidant effect, XinMaiJia increased superoxide dismutase activity but decreased malondialdehyde level in plasma. For antiinflammation effect, XinMaiJia increased the expression of endothelial nitric oxide synthase and nitric oxide, but reduced intercellular adhesion molecule-1, vascular cell adhesion molecule-1, matrix metalloprotein-2 and nuclear factor-kappa B levels. Furthermore, XinMaiJia reduced endothelin-1 expression. More importantly, all these changes have a feedback with low density lipoprotein receptor-1. XinMaiJia increased the antioxidant and antiinflammation capacity of the body to prevent the development of atherosclerosis. The possible mechanisms of XinMaiJia were mainly through inhibiting the vital gene low density lipoprotein receptor-1. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| 9 (RLIN) |
4639 |
| Topical term or geographic name entry element |
PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| 9 (RLIN) |
12759 |
| Co-Author |
Zhu, T. T. |
| 773 0# - HOST ITEM ENTRY |
|---|
| Place, publisher, and date of publication |
New Delhi Indian Pharmaceutical Association |
| Title |
Indian journal of pharmaceutical sciences |
| International Standard Serial Number |
0250-474X |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
|---|
| URL |
https://www.ijpsonline.com/articles/nuclear-role-of-lox1-in-ixinmaijiaiattenuating-atherosclerosis-in-rabbits.pdf |
| Link text |
Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
|
| Koha item type |
Articles Abstract Database |
