| 000 -LEADER |
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| fixed length control field |
a |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20201215101730.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
201215b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
AIKTC-KRRC |
| Transcribing agency |
AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME |
|---|
| 9 (RLIN) |
12764 |
| Author |
Feng, R. |
| 245 ## - TITLE STATEMENT |
|---|
| Title |
TCF4/β-Catenin Complex Activates Smo and Gli1 to Promote Migration and Proliferation of Hepatocellular Carcinoma Cells |
| 250 ## - EDITION STATEMENT |
|---|
| Volume, Issue number |
Vol.81(6), Nov-Dec |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Mumbai |
| Name of publisher, distributor, etc. |
Indian Journal of Pharmaceutical Science |
| Year |
2019 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Pagination |
1045-4052p. |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
Hepatocelluar carcinoma severely affects patients because of high incidence of cancer-mediated deaths. Wnt and hedgehog signalling pathways have been known to be associated with hepatocelluar carcinoma cell proliferation and migration; however, molecular connections between the two pathways are largely unknown. In this investigation the expression levels of key Wnt signalling genes (Wnt3, TCF7, and FZD8) and hedgehog signalling genes (Smo, Gli1, Gli2, and Gli3) were identified to be higher in hepatocelluar carcinoma cell lines (HepG2 and SMMC-7721) than in normal liver cell line (LO2). Western blot results indicated that β-catenin, Smo, and Gli1 levels were all higher in hepatocelluar carcinoma cells than in normal liver cells. In addition, overexpression of β-catenin activated Smo and Gli1 as well as accelerated HepG2 cell migration and proliferation. Further, immunoprecipitation assay showed that β-catenin/TCF4 complex directly bound to Smo and Gli1 promoters. Suppression of β-catenin or Gli1 inhibited HepG2 cell migration and proliferation, and Gli1 silencing inhibited β-catenin overexpression effects on cell migration and proliferation, and silencing of β-catenin inhibited Wnt3a-meidated induction of hedgehog signalling gene expressions, suggesting that β-catenin acts at the upstream of Smo and Gli1. Taken together, these results provided information for direct connection between Wnt and hedgehog signalling via β-catenin/TCF4 complex that broaden the regulatory mechanism for Wnt and hedgehog signalling pathways |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| 9 (RLIN) |
4639 |
| Topical term or geographic name entry element |
PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| 9 (RLIN) |
12765 |
| Co-Author |
Haitao, J. |
| 773 0# - HOST ITEM ENTRY |
|---|
| Place, publisher, and date of publication |
New Delhi Indian Pharmaceutical Association |
| Title |
Indian journal of pharmaceutical sciences |
| International Standard Serial Number |
0250-474X |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
|---|
| URL |
https://www.ijpsonline.com/articles/tcf4betacatenin-complex-activates-smo-and-gli1-to-promote-migration-and-proliferation-of-hepatocellular-carcinoma-cells.pdf |
| Link text |
Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
|
| Koha item type |
Articles Abstract Database |
