Stability of Hydromorphone Hydrochloride and Morphine under different clinical infusion conditions (Record no. 13838)

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control field 20201221112508.0
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fixed length control field 201219b xxu||||| |||| 00| 0 eng d
040 ## - CATALOGING SOURCE
Original cataloging agency AIKTC-KRRC
Transcribing agency AIKTC-KRRC
100 ## - MAIN ENTRY--PERSONAL NAME
9 (RLIN) 12811
Author Ping, L.
245 ## - TITLE STATEMENT
Title Stability of Hydromorphone Hydrochloride and Morphine under different clinical infusion conditions
250 ## - EDITION STATEMENT
Volume, Issue number Vol.81(6), November - December
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Place of publication, distribution, etc. Mumbai
Name of publisher, distributor, etc. Indian Journal of Pharmaceutical Science
Year 2019
300 ## - PHYSICAL DESCRIPTION
Pagination 1140-1146p.
520 ## - SUMMARY, ETC.
Summary, etc. The primary objective of present study was to evaluate the stability of hydromorphone hydrochloride injection as well as to compare the stability of hydromorphone and morphine under different infusion conditions. Hydromorphone hydrochloride and morphine hydrochloride injections were dissolved in 0.9 % sodium chloride and stored in patient-controlled analgesia pump, glass bottles and ordinary syringes (polyvinyl chloride) at 25° and 37°. The concentrations of 0.05 and 0.025 mg/ml were used, which were clinical conventional intrathecal doses in this hospital. Samples were collected at 0, 1, 2, 3, 5, 7, 9, 11, 13 and 15 days and analyzed using high performance liquid chromatography. At each time point, the appearance
and pH values of the solutions were also examined, which indicated that hydromorphone hydrochloride injection and morphine hydrochloride injection stored in the infusion sets made of different materials for 15 d showed no signicant changes either at 25° or 37°. The high performance liquid chromatography analysis indicated that the concentrations of both drugs were maintained at greater than 90 % of their initial
concentrations on day 0 either at room temperature or body temperature. Hydromorphone hydrochloride injection and morphine hydrochloride injection were stable at least for 15 days when dissolved in normal saline in polyvinyl chloride infusion bag, non-polyvinyl chloride infusion bag and patient-controlled
analgesia pump either at room temperature or body temperature
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM
9 (RLIN) 4639
Topical term or geographic name entry element PHARMACEUTICS
700 ## - ADDED ENTRY--PERSONAL NAME
9 (RLIN) 12812
Co-Author Juan, Hou
700 ## - ADDED ENTRY--PERSONAL NAME
9 (RLIN) 12815
Co-Author Zhou, Xia-Jin
700 ## - ADDED ENTRY--PERSONAL NAME
9 (RLIN) 12814
Co-Author Feng, Z.Y.
700 ## - ADDED ENTRY--PERSONAL NAME
9 (RLIN) 12813
Co-Author Lin Li, Rui
773 0# - HOST ITEM ENTRY
Place, publisher, and date of publication New Delhi
Title Indian journal of pharmaceutical sciences
856 ## - ELECTRONIC LOCATION AND ACCESS
URL https://www.researchgate.net/publication/338735375_Stability_of_Hydromorphone_Hydrochloride_and_Morphine_under_Different_Clinical_Infusion_Conditions
Link text Click here
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          School of Pharmacy School of Pharmacy Archieval Section 2020-12-19 2020-2021155 2020-12-19 2020-12-19 Articles Abstract Database
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