| 000 -LEADER |
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a |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20211120130528.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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211120b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
AIKTC-KRRC |
| Transcribing agency |
AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME |
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| 9 (RLIN) |
14686 |
| Author |
Voycheva, Christina |
| 245 ## - TITLE STATEMENT |
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| Title |
Formulation of Tablets Containing Mesoporous Silica Nanoparticles Loaded with Pramipexole |
| 250 ## - EDITION STATEMENT |
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| Volume, Issue number |
Vol.55(3), Jul-Sep |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Place of publication, distribution, etc. |
Banagalore |
| Name of publisher, distributor, etc. |
Association of Pharmaceutical Teachers of India (APTI) |
| Year |
2021 |
| 300 ## - PHYSICAL DESCRIPTION |
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| Pagination |
692-700p. |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc. |
Background: In order to develop final pharmaceutical product, the mesoporous silica particles loaded with pramipexole should be further formulated in the applicable solid dosage forms - tablets. The aim of the study was preparation of tablets containing MCM- 41 particles loaded with pramipexole. Materials and Methods: Mesoporous silica particles empty and loaded were subjected to dynamic light scattering analysis (DLS), transmission electron microscopy analysis (TEM) and infrared spectroscopy (IR). Modification of drug release was achieved by further formation of double chitosan/alginate coating. The formulation of tablets was made using diluents, a binder, disintegrate, glidant and a lubricant as well as the silica particles loaded with pramipexole. Flow ability and compressibility of the initial powder mixtures and were examined by tapping method calculating the Carr index and Hausner ratio. Direct compression method was used for tablet preparation. The crushing strength, friability of the tablets and their disintegration time were determined. In-vitro release profiles showed that tablet form influenced first stages of pramipexole release in both pH values, used in the study (pH 1.2 and pH 6.8). Results: Final pharmaceutical dosage form tablets were successfully formulated with pramipexole loaded MCM-41. No change in mesopourous structure and other characterisic properties of used nanoparticles was observed. Improved profile in first release stage were observed. Conclusion: The use of polymers such as chitosan and sodium alginate in silica particles modification successfully delay the process of releasing pramipexole from MCM-41. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| 9 (RLIN) |
4639 |
| Topical term or geographic name entry element |
PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| 9 (RLIN) |
14687 |
| Co-Author |
Popova, Teodora |
| 773 0# - HOST ITEM ENTRY |
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| Title |
Indian journal of pharmaceutical education and research |
| International Standard Serial Number |
0019-5464 |
| Place, publisher, and date of publication |
Bengluru Association of Pharmaceutical Teachers of India (APTI) |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| URL |
https://www.ijper.org/sites/default/files/IndJPhaEdRes-55-3-692.pdf |
| Link text |
Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
|
| Koha item type |
Articles Abstract Database |
