| 000 -LEADER |
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| fixed length control field |
a |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20211122152146.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
211122b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
AIKTC-KRRC |
| Transcribing agency |
AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME |
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| 9 (RLIN) |
14731 |
| Author |
Mehta, Mukul |
| 245 ## - TITLE STATEMENT |
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| Title |
Synthesis and Anti-hyperglycaemic Study of Aryl Sulfonate Ester Conjugated 5-arylidene-thiazolidine-2,4-diones |
| 250 ## - EDITION STATEMENT |
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| Volume, Issue number |
Vol.55(3), Jul-Sep |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Place of publication, distribution, etc. |
Banagalore |
| Name of publisher, distributor, etc. |
Association of Pharmaceutical Teachers of India (APTI) |
| Year |
2021 |
| 300 ## - PHYSICAL DESCRIPTION |
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| Pagination |
894-903p. |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc. |
Background: Diabetes mellitus, a lifestyle related global health crisis has rapidly engulfed the entire world. In the past, various thiazolidinedione derivatives have been successfully developed for management of diabetes. Materials and Methods: Herein, we report synthesis, characterization (1H-NMR, 13C-NMR and mass spectroscopy methods) of novel aryl sulfonyloxy-5-arylidene thiazolidine-2,4-dione analogues. Anti-hyperglycaemic action (Alloxan-induced method) was performed for evaluating the antidiabetic potential of the synthesized compounds. Docking analysis of the final compounds were carried out to reveal interactions with the active site pocket of enzymes like protein tyrosine phosphatase 1B, aldose reductase and peroxisome proliferator activated-γ. The synthesized compounds were further subjected to ADME (Absorption, Distribution, Metabolism, Elimination) prediction studies to prove their drug-like potential. Results: Compound 10 and 12 showed comparable reduction in blood sugar as that with pioglitazone. Docking studies helped in understanding the probable binding mode inside the binding cavity of the concerned receptors. Conclusion: Aryl sulfonate esters with phenyl and chloro phenyl substituents were found to have superior anti-hyperglycaemic activity. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| 9 (RLIN) |
4639 |
| Topical term or geographic name entry element |
PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| 9 (RLIN) |
14732 |
| Co-Author |
Mahapatra, Manoj Kumar |
| 773 0# - HOST ITEM ENTRY |
|---|
| Place, publisher, and date of publication |
Bengluru Association of Pharmaceutical Teachers of India (APTI) |
| International Standard Serial Number |
0019-5464 |
| Title |
Indian journal of pharmaceutical education and research |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| URL |
https://www.ijper.org/sites/default/files/IndJPhaEdRes-55-3-894.pdf |
| Link text |
Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
|
| Koha item type |
Articles Abstract Database |
