000 -LEADER |
fixed length control field |
a |
003 - CONTROL NUMBER IDENTIFIER |
control field |
OSt |
005 - DATE AND TIME OF LATEST TRANSACTION |
control field |
20211124101222.0 |
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
fixed length control field |
211124b xxu||||| |||| 00| 0 eng d |
040 ## - CATALOGING SOURCE |
Original cataloging agency |
AIKTC-KRRC |
Transcribing agency |
AIKTC-KRRC |
100 ## - MAIN ENTRY--PERSONAL NAME |
9 (RLIN) |
14788 |
Author |
Chitre, Trupti Sameer |
245 ## - TITLE STATEMENT |
Title |
Designing of Thiazolidin-4-one Pharmacophore using QSAR Studies for Anti-HIV Activity |
250 ## - EDITION STATEMENT |
Volume, Issue number |
Vol.55(2), Apr-Jun |
260 ## - PUBLICATION, DISTRIBUTION, ETC. |
Place of publication, distribution, etc. |
Banaglore |
Name of publisher, distributor, etc. |
Association of Pharmaceutical Teachers of India (APTI) |
Year |
2021 |
300 ## - PHYSICAL DESCRIPTION |
Pagination |
581-589p. |
520 ## - SUMMARY, ETC. |
Summary, etc. |
Background and Aim: In an effort of drug development in the area of HIV, present work deals with development of 2D and 3D QSAR of thiazolidinone derivatives against HIV-RT activity as a powerful method for elucidation the relationships between structure and activity. Materials and Methods: 2D QSAR and 3D QSAR were performed using MLR and SA kNN method respectively. Models which had higher predictability were generated as indicated from their statistical parameters. Results and Discussion: Best models generated showed correlation coefficient r2= 0.9256 and q2 =0.8623 for 2D QSAR and q2 =0.8444 for 3D QSAR. The models indicated the requirement of electro topological, electrostatic and steric descriptors which would significantly contribute to HIV-RT inhibitory activity. Further a few compounds were designed using the outcome of QSAR studies. |
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
9 (RLIN) |
4639 |
Topical term or geographic name entry element |
PHARMACEUTICS |
700 ## - ADDED ENTRY--PERSONAL NAME |
9 (RLIN) |
14789 |
Co-Author |
Patil, Shital Manoj |
773 0# - HOST ITEM ENTRY |
International Standard Serial Number |
0019-5464 |
Title |
Indian journal of pharmaceutical education and research |
Place, publisher, and date of publication |
Bengluru Association of Pharmaceutical Teachers of India (APTI) |
856 ## - ELECTRONIC LOCATION AND ACCESS |
URL |
https://www.ijper.org/sites/default/files/IndJPhaEdRes-55-2-581.pdf |
Link text |
Click here |
942 ## - ADDED ENTRY ELEMENTS (KOHA) |
Source of classification or shelving scheme |
|
Koha item type |
Articles Abstract Database |