Design, in silico analysis, synthesis, and evaluation of novel benzofused nitrogen-containing heterocyclic N-substituted mercaptobenzimidazole derivatives as potential antimicrobial agent (Record no. 15644)
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| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20211220145223.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 211220b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 14879 |
| Author | Patil, Tejaswini D. |
| 245 ## - TITLE STATEMENT | |
| Title | Design, in silico analysis, synthesis, and evaluation of novel benzofused nitrogen-containing heterocyclic N-substituted mercaptobenzimidazole derivatives as potential antimicrobial agent |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.15 (3), Jul-Sept |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Mandsaur |
| Name of publisher, distributor, etc. | B.R. Nahata Smriti Sansthan |
| Year | 2021 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 226-237p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: There is an urgent need for buy soma online overnight delivery the development of novel antimicrobial drugs due to the rapid development of antimicrobial drug resistance. Benzimidazole containing mercapto group at 2-position is attractive nucleus for modification with wider pharmacological activities. Objective: The aim of this study is to design benzofused nitrogen-containing heterocyclic derivatives of mercaptobenzimidazole using molecular docking, synthesis of active derivative and evaluation as potential antimicrobial agent. Materials and Methods: Using an effective procedure, N-substituted mercaptobenzimidazole derivatives were synthesized based on the literature review. The antimicrobial activity of all synthesized compounds was tested against four different organisms: Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Candida albicans. Molecular docking of mercaptobenzimidazole derivatives against DNA gyrase subunit B Protein Data Bank (PDB): 5l3j and S. aureus tyrosyl-tRNA synthetase PDB: 1jij was performed using docking protocol. The compound binds to buy soma online usa the active site of DNA gyrase subunit B (1KZN) in a docking study, indicating that it may have antimicrobial activity. Conclusion: The compounds MB3 and MB5 have antimicrobial capacity, according to the findings of this report. MB4 has the high activity against C. albicans. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 14880 |
| Co-Author | Amrutkar, Sunil V. |
| 773 0# - HOST ITEM ENTRY | |
| Place, publisher, and date of publication | Mandsaur B.R. Nahata Smriti Sansthan |
| Title | International journal of green pharmacy |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | http://greenpharmacy.info/index.php/ijgp/article/view/3149 |
| Link text | Full Text |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Permanent Location | Current Location | Shelving location | Date acquired | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| School of Pharmacy | School of Pharmacy | Archieval Section | 2021-12-20 | 2021-2022462 | 2021-12-20 | 2021-12-20 | Articles Abstract Database |