| 000 -LEADER |
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| fixed length control field |
a |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20211220151638.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
211220b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
AIKTC-KRRC |
| Transcribing agency |
AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME |
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| 9 (RLIN) |
14886 |
| Author |
Ansari, Nafid |
| 245 ## - TITLE STATEMENT |
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| Title |
Formulation of carbamazepine fast dissolving tablets employing guar gum and croscarmellose sodium as disintegrants |
| 250 ## - EDITION STATEMENT |
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| Volume, Issue number |
Vol.15(3), Jul-Sept |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Mandsaur |
| Name of publisher, distributor, etc. |
B.R. Nahata Smriti Sansthan |
| Year |
2021 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Pagination |
249-258p. |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc. |
Aim: The aim of this investigation was to formulate and evaluate fast dissolving tables (FDT) of carbamazepine (CBZ) employing guar gum as the disintegrating agent and compared with tramadol price synthetic superdisintegrant croscarmellose sodium (CCS). Materials and Methods: CBZ was characterized by melting point, Fourier Transform Infrared (FTIR) spectroscopy and ultraviolet UV Spectroscopy. GG and CCS were studied for particle size and shape, bulk densities, settling volume and bed hyrophilicity. CBZ and has been incorporated in the FDTs as its solid dispersion using mannitol as carrier. FDT powder blends were evaluated for precompressional parameters. The solid dispersion of drug was incorporated into tablets. Tablets were prepared by direct compression. FDT of CBZ were evaluated for weight variation, thickness, hardness, friability, drug content, wetting time, in vitro disintegration time and in vitro drug dissolution. Results and Discussion: IR spectroscopy showed that there is no interaction of drug with excipients. Precompression blends exhibited good flowability and compressibility. All the formulations disintegrated within 1-2 minutes. Thus GG is comparable to tramadol 50mg price synthetic superdisintegrants for formulation of FDT. Selected formulation was F8 with hardness of 3.5 ± 0.18 kg/cm2, wetting time of 42 ± 2.28 s, disintegration time of 10.56 ± 1 s, drug content of 99.78 ± 0.8 % and gave 96.82 ± 0.42 % cumulative drug dissolution in 25 minutes and stability study on F8 at 40±2°C/ 75±5% RH for two months revealed that there was very mild change in disintegration time and in vitro drug release needing further study to ascertain the physical stability and storage conditions. Conclusion: FDT of CBZ could be formulated using GG as the disintegrating agent which was comparable to CCS for tablet disintegration. A combination of natural and synthetic superdistegrants yielded FDT of CBZ with shortest disintegration time. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| 9 (RLIN) |
4639 |
| Topical term or geographic name entry element |
PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| 9 (RLIN) |
14887 |
| Co-Author |
Madhavi, B.L.R. |
| 773 0# - HOST ITEM ENTRY |
|---|
| Title |
International journal of green pharmacy |
| Place, publisher, and date of publication |
Mandsaur B.R. Nahata Smriti Sansthan |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
|---|
| URL |
http://greenpharmacy.info/index.php/ijgp/article/view/3152 |
| Link text |
Full text |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
|
| Koha item type |
Articles Abstract Database |
