In silico elucidation of Boesenbergia rotunda phytoconstituents against diabetes mellitus (Record no. 15652)
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| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20211221101836.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 211221b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 14896 |
| Author | Sandhya, Tera |
| 245 ## - TITLE STATEMENT | |
| Title | In silico elucidation of Boesenbergia rotunda phytoconstituents against diabetes mellitus |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.15(3), Jul-Sept |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Mandsaur |
| Name of publisher, distributor, etc. | B.R. Nahata Smriti Sansthan |
| Year | 2021 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 271-277p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Introduction: Herbal medicine has become a well-chosen treatment to reduce the negative effects of diabetes mellitus (DM) and its serious complications due to its side effects and low cost. Material and Methods: Plants of the Zingiberaceae family, for example, Boesenbergia rotunda, Renealmia alpinia, and Zingiber zerumbet have been extensively investigated for their phytoconstituents and molecular mechanisms. This study aims to examine the price for tramadol molecular interactions that exist between the various bioactive chemicals in B. rotunda and that targeted proteins associated with type 2 DM. Molecular docking studies were done to assess the binding mode and interactions of synthesized hits at binding site of receptors. Results: Results of in silico studies showed that polyphenols and flavonoids have excellent drug-likeness properties, pharmacokinetic profile against DM targets such as peroxisome proliferator-activated receptor gamma (PPARG), dipeptidyl peptidase 4 (DPP4), and α-glucosidase. Molecular docking results highlighted five of top 10 interactions correspond to pinocembrin, alpinetin, and pinostrobin with DPP4, α-glucosidase, and PPARG; pinocembrin and silybin with PPARG. These proteins involved in regulating the functions such as inflammation, insulin resistance, oxidative stress, glucose, and lipid metabolism. Conclusion: This work provides a cheapest tramadol dynamic state of B. rotunda, especially flavonoids that show their diabetic benefits. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 14897 |
| Co-Author | Thakur, Santh Rani |
| 773 0# - HOST ITEM ENTRY | |
| Title | International journal of green pharmacy |
| Place, publisher, and date of publication | Mandsaur B.R. Nahata Smriti Sansthan |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | http://greenpharmacy.info/index.php/ijgp/article/view/3155 |
| Link text | Full Text |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Permanent Location | Current Location | Shelving location | Date acquired | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| School of Pharmacy | School of Pharmacy | Archieval Section | 2021-12-21 | 2021-2022470 | 2021-12-21 | 2021-12-21 | Articles Abstract Database |