Preparation and evaluation of castalin (hydrolysable tannin)-loaded poly (lactic-co-glycolic acid) nanoparticles and exploring its anticancer potential (Record no. 15658)
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| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20211221105407.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 211221b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 14903 |
| Author | J. Praveen Kumar |
| 245 ## - TITLE STATEMENT | |
| Title | Preparation and evaluation of castalin (hydrolysable tannin)-loaded poly (lactic-co-glycolic acid) nanoparticles and exploring its anticancer potential |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.15(3), Jul-Sep |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Mandsaur |
| Name of publisher, distributor, etc. | B.R. Nahata Smriti Sansthan |
| Year | 2021 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 288-297p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Aim: Over the past few decades, nanoparticles (NPs) have gained immeasurable interest in the field of drug delivery. Various NP formulations have been disseminated in drug development in an attempt to increase efficiency, safety, and tolerability of incorporated drugs. In this context, NP formulations that increase solubility, control release, and/ or affect the in vivo disposition of drugs were developed to improve the pharmacokinetic and pharmacodynamic properties of encapsulated drugs. Among the potent anticancer agents, castalin has been found to be very efficacious against many different types of cancer cells. Our present work investigated the efficiency of encapsulation of castalin in poly(lactic-co-glycolic acid) (PLGA) NPs using solid/oil/water emulsion solvent evaporation method. Materials and Methods: The NPs were formulated and then characterized for percent yield, encapsulation efficiency, surface morphology, particle size, drug distribution studies, drug polymer interaction studies, and in vitro drug release profiles. The objective of this work is to prepare and evaluate PLGA NPs of castalin, an anticancer agent loaded by solvent displacement method using stabilizer (polyvinyl alcohol). Results and Discussion: The prepared NPs were characterized by Fourier transmission infrared (FT-IR), differential scanning calorimetry (DSC), drug loading, entrapment efficiency, particle size, and surface morphology by atomic force microscopy (AFM), X-ray diffraction, and in vitro studies. FT-IR and DSC studies indicated that there was no interaction between the drug and polymer. The morphological studies performed by AFM showed uniform and spherical-shaped discrete particles without aggregation and smooth in surface morphology with a nano size range of 144 nm. Conclusion: In this context, the huge number of reports on PLGA NPs used as drug delivery systems in cancer treatment highlights the potential of PLGA NPs as drug carriers for cancer therapeutics and encourages further translational research. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 14904 |
| Co-Author | Geetha, P. |
| 773 0# - HOST ITEM ENTRY | |
| Title | International journal of green pharmacy |
| Place, publisher, and date of publication | Mandsaur B.R. Nahata Smriti Sansthan |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | http://greenpharmacy.info/index.php/ijgp/article/view/3157 |
| Link text | Fuul Text |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Permanent Location | Current Location | Shelving location | Date acquired | Barcode | Date last seen | Price effective from | Koha item type |
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| School of Pharmacy | School of Pharmacy | Archieval Section | 2021-12-21 | 2021-2022476 | 2021-12-21 | 2021-12-21 | Articles Abstract Database |