| 000 -LEADER |
|---|
| fixed length control field |
a |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
|---|
| control field |
20211221111518.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
211221b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
AIKTC-KRRC |
| Transcribing agency |
AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME |
|---|
| 9 (RLIN) |
14912 |
| Author |
Malviya, Vedanshu |
| 245 ## - TITLE STATEMENT |
|---|
| Title |
Preparation and Evaluation of Emulsomes as a Drug Delivery System for Bifonazole |
| 250 ## - EDITION STATEMENT |
|---|
| Volume, Issue number |
Vol.55(1), Jan-Mar |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Karnataka |
| Name of publisher, distributor, etc. |
Association of Pharmaceutical Teachers of India (APTI) |
| Year |
2021 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Pagination |
86-94p. |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
Purpose: The main objective of present study is to evaluate the effect of various factors which have direct influence on the characteristic parameters of emulsomes formulation, so that optimized combination of factors can be find out which meet the high level of set desirability criteria. The present work is focused on the optimization of emulsomes formulation by applying Box-Behnken design (BBD) of experiment. Emulsomes are the modified form of emulsomes which consists of solid lipid core surrounded by phospholipid bilayer. Methods: Emulsomes were prepared by lipid film hydration method using Phosphatidylcholine (PHL), Tristearin (TRI), Stearylamine (STR), Cholesterol (CHOL) and Bifonazole as drug candidate. Formulations were optimized by using three factor three levels Box-Behnken (BBD) design of experiment. BBD was applied considering 3 factors as independent variables viz. Phospholipid ratio to Drug (A), Phospholipid to Tristearin ratio (B) and Phospholipid ratio to Stearylamine (C) at 3 levels (-1, 0, +1) to study their effect on dependent variables viz. Particle size (Y1), Zeta Potential (Y2) and Entrapment efficiency (Y3). Results of independent variables (A, B, C) were analysed to construct quadratic equation and 3-D response surface curves for each dependent variable (Y1, Y2, Y3). Results: The optimized formulation was selected on the basis of desirability criteria of minimum particle size, maximum zeta potential and maximum entrapment efficiency. The final optimized formulation has predicted particle size (390.394 nm), zeta potential (45.0mV) and entrapment efficiency (81.642%). Conclusion: BBD is remarkable design of experiment for studying the effect of 3-factors at 3-levels on the responses in optimizing the emulsomes formulation. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| 9 (RLIN) |
4639 |
| Topical term or geographic name entry element |
PHARMACEUTICS |
| 773 0# - HOST ITEM ENTRY |
|---|
| Place, publisher, and date of publication |
Bengluru Association of Pharmaceutical Teachers of India (APTI) |
| International Standard Serial Number |
0019-5464 |
| Title |
Indian journal of pharmaceutical education and research |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
|---|
| URL |
https://www.ijper.org/sites/default/files/IndJPhaEdRes_55_1_86.pdf |
| Link text |
Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
|
| Koha item type |
Articles Abstract Database |
