| 000 -LEADER |
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| fixed length control field |
a |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20211221121258.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
211221b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
AIKTC-KRRC |
| Transcribing agency |
AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME |
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| 9 (RLIN) |
14927 |
| Author |
Sreeharsha, Nagaraja |
| 245 ## - TITLE STATEMENT |
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| Title |
Doxorubicin Hydrochloride Loaded Polyanhydride Nanoformulations and Cytotoxicity |
| 250 ## - EDITION STATEMENT |
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| Volume, Issue number |
Vol.55(1), Jan-Mar |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Karnataka |
| Name of publisher, distributor, etc. |
Association of Pharmaceutical Teachers of India (APTI) |
| Year |
2021 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Pagination |
117-125p. |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc. |
This study aimed to evaluate DOX∙HCl loaded P(DLLA-CO:60:40) nanoformulations with a copolymer of F127 as a potential drug delivery system for cancer. DOX ∙ HCl was encapsulated in nanoformulations of Poly DL-lactic acid co castor oil 60:40, P(DLLACO: 60:40) polymer with the copolymer/stabilizer Pluronic® F127. The mean diameter of the cylindrical rod shape of the nanoformulation particles was 248±2.4-260±3.2 nm with an acceptable poly dispersibility of 0.29- 0.33 and a smooth surface as visualized by DSC, SEM and XRD displayed that DOX∙HCl was present as an disordered crystalline or amorphous state in the nanoformulations. The nanoformulations showed a steady pattern of drug discharge for 24 hrs. F-3 and F-4 formulations had IC50 values of 3.2±0.03 and 1.98±0.08 mcg/ml while the free drug inhibition concentration of IC50 was 2.2 mcg/ml. The drug-loaded nanoformulations showed significant cytotoxic effects on MCF-7 breast cancer cell lines. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| 9 (RLIN) |
4639 |
| Topical term or geographic name entry element |
PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| 9 (RLIN) |
14928 |
| Co-Author |
Hiremath, Jagadeesh G. |
| 773 0# - HOST ITEM ENTRY |
|---|
| International Standard Serial Number |
0019-5464 |
| Title |
Indian journal of pharmaceutical education and research |
| Place, publisher, and date of publication |
Bengluru Association of Pharmaceutical Teachers of India (APTI) |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| URL |
https://www.ijper.org/sites/default/files/IndJPhaEdRes_55_1_117.pdf |
| Link text |
Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
|
| Koha item type |
Articles Abstract Database |
