| 000 -LEADER |
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a |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20211221122423.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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211221b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
AIKTC-KRRC |
| Transcribing agency |
AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME |
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| 9 (RLIN) |
14930 |
| Author |
Sudhir Kumar |
| 245 ## - TITLE STATEMENT |
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| Title |
Protective Effect of Natrium Diethyldithiocarbamate Trihydrate (NDDCT) on Lead Induced Neurodegeneration in Rats |
| 250 ## - EDITION STATEMENT |
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| Volume, Issue number |
Vol.55(1), Jan-Mar |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Place of publication, distribution, etc. |
Karnataka |
| Name of publisher, distributor, etc. |
Association of Pharmaceutical Teachers of India (APTI) |
| Year |
2021 |
| 300 ## - PHYSICAL DESCRIPTION |
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| Pagination |
126-135p. |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc. |
Aim: Lead is a powerful metal which induced neurotoxicity through the degradation of neurons in the body. Various neuronal changes have shown correlation with the generation of free radicals and oxidative stress. The present study was carried out to evaluate the neuroprotective activity of Natrium diethyl dithiocarbamate trihydrate (NDDCT) on lead induced neurodegeneration in rat’s model. Methods: We have evaluated the neuroprotective activity of NDDCT using Morris Water maze, Elevated plus maze, Photoactometer and Hebb’s William maze models and also evaluated different biochemical parameters. Neurodegeneration was induced by administering lead acetate (1 mg/kg/day) for 35 days. Test drug NDDCT (5 mg/kg and 10 mg/kg) and standard drug donepezil were also administered concurrently in test and standard drug treated group. Results: NDDCT found to improve escape latency time (in Morris Water Maze), transfer latency time (in Elevated plus Maze), time to reach reward chamber (Hebb William’s Maze) and locomotor activity. The neuroprotective activity of NDDCT was confirmed by evaluation of in vivo antioxidant and estimation of other biochemical parameters. NDDCT found to improve the level of reduced glutathione, catalase, superoxide dismutase, sodium nitrate and reduced the level of serum lead, TNF-α, nitric oxide, acetylcholinesterase enzyme in the test group when compared with the disease control group. Histopathological evaluation of the brain also confirms the protective effect of NDDCT. Conclusion: These results suggest that NDDCT can be used as a preventive drug against lead-induced neurodegeneration, cholinergic dysfunctions and oxidative stress. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| 9 (RLIN) |
4639 |
| Topical term or geographic name entry element |
PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| 9 (RLIN) |
14931 |
| Co-Author |
Maurya, Harikesh |
| 773 0# - HOST ITEM ENTRY |
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| Title |
Indian journal of pharmaceutical education and research |
| Place, publisher, and date of publication |
Bengluru Association of Pharmaceutical Teachers of India (APTI) |
| International Standard Serial Number |
0019-5464 |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| URL |
https://www.ijper.org/sites/default/files/IndJPhaEdRes_55_1_126.pdf |
| Link text |
Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
|
| Koha item type |
Articles Abstract Database |
