| 000 -LEADER |
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| fixed length control field |
a |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20211222122316.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
211222b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
AIKTC-KRRC |
| Transcribing agency |
AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME |
|---|
| 9 (RLIN) |
14967 |
| Author |
Piyush Kumar |
| 245 ## - TITLE STATEMENT |
|---|
| Title |
Docking Studies, Synthesis and Evaluation of Anticancer Activity of 4H-Chromene Derivatives |
| 250 ## - EDITION STATEMENT |
|---|
| Volume, Issue number |
Vol.55(1), Jan-Mar |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Karnataka |
| Name of publisher, distributor, etc. |
Association of Pharmaceutical Teachers of India (APTI) |
| Year |
2021 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Pagination |
256-265p. |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
Aim: The present study involves to design, synthesis and evaluate the anticancer activity of 4H-chromene derivatives (PKB 1-10) on human breast cancer MCF-7 cell line. Materials and Methods: 4H-chromene derivatives (PKB 1-10) were designed by docking, in silico ADME and predicted toxicity studies. These designed compounds were then synthesized by acid catalyzed Michael Addition of phenols to benzylidene oxobutanoates. These compounds were characterized by 1H NMR, 13C NMR, FTIR and melting point. Then all synthesized compounds were tested for anticancer activity on MCF-7 cell line. Results: Compounds PKB-4 and PKB-10 showed better docking scores than standard drug, Adriamycin. In silico ADME and toxicity studies were also found significant for most of the compounds. The majority of the compounds displayed promising to potent anticancer activity on MCF-7 cell line. Conclusion: It may be concluded that most of the compounds showed significant docking and in silico ADME and toxicity profiles. Compounds have excellent anticancer potential and could be considered as novel anticancer agents for more investigation. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| 9 (RLIN) |
4639 |
| Topical term or geographic name entry element |
PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| 9 (RLIN) |
14968 |
| Co-Author |
Rawat, Pinki |
| 773 0# - HOST ITEM ENTRY |
|---|
| Place, publisher, and date of publication |
Bengluru Association of Pharmaceutical Teachers of India (APTI) |
| International Standard Serial Number |
0019-5464 |
| Title |
Indian journal of pharmaceutical education and research |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
|---|
| URL |
https://www.ijper.org/sites/default/files/IndJPhaEdRes_55_1_256.pdf |
| Link text |
Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
|
| Koha item type |
Articles Abstract Database |
