Evaluation of Antihyperglycemic Effect of Epilobium parviflorum in High Fat Diet Fructose Streptozotocin Induced Type 2 Diabetic Albino Wistar Rats (Record no. 15744)
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| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20211224112228.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 211224b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 15065 |
| Author | RANAJIT, S. K. |
| 245 ## - TITLE STATEMENT | |
| Title | Evaluation of Antihyperglycemic Effect of Epilobium parviflorum in High Fat Diet Fructose Streptozotocin Induced Type 2 Diabetic Albino Wistar Rats |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.83(3), May-June |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Mumbai |
| Name of publisher, distributor, etc. | Indian Journal of Pharmaceutical Science |
| Year | 2021 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 547-555p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | The proposed work deals with pharmacological evaluation of aqueous leaf extract ofEpilobium parviflorum for antihyperglycemic and antihyperlipidemic activity in high fat diet fructose streptozotocin induced type 2 Diabetes mellitus in albino wistar rats. The experimental protocol was designed on a total of 30 rats, equally divided into 5 groups (6 rats in each group). The high fat diet fructose was administered to all the groups except the normal control group throughout a 6 w study period. A low dose of streptozotocin (35 mg/kg body weight) is freshly prepared and administered intraperitoneally once after the initial 2 w of high fat diet fructose administration. The animals were observed for 1 w to induce diabetes. The two doses of aqueous leaf extract of Epilobium parviflorum (200 & 400 mg/kg) and pioglitazone (10 mg/kg) were administered orally once daily throughout the rest 3 w. Various serum parameters including lipid profile, liver profile, renal profile and inflammatory biomarkers were estimated on 0th and 6 th w of the study. All the individual test results are falling within the normal distribution of the test groups (treatment with leaf extract) when compared with disease control group with least variance (p<0.01). However, when compared to the standard group (pioglitazone treated), the results show too much variance. Increase in insulin release and decreased fasting blood sugar results are purely dose dependant. The histopathological studies of hepatocyte, nephron, adipocytes and islet of pancreatic beta cells were also exhibited excellent antihyperglycemic and antihyperlipidemic activity while the test group maintained normal cell architectures. With the assumption on the traditional curative assurance and scientific evidences, it may be concluded that Epilobium parviflorum contributes to the antihyperglycemic as well as antihyperlipidemic activity by maintaining the normal structure and function of hepatocytes, renal, pancreas and adipose function. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 9548 |
| Co-Author | Killari, K. N. |
| 773 0# - HOST ITEM ENTRY | |
| Place, publisher, and date of publication | New Delhi |
| Title | Indian journal of pharmaceutical sciences |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijpsonline.com/articles/evaluation-of-antihyperglycemic-effect-of-emepilobium-parviflorumem-in-high-fat-diet-fructose-streptozotocin-induced-typ.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Permanent Location | Current Location | Shelving location | Date acquired | Barcode | Date last seen | Price effective from | Koha item type |
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| School of Pharmacy | School of Pharmacy | Archieval Section | 2021-12-24 | 2021-2022564 | 2021-12-24 | 2021-12-24 | Articles Abstract Database |