Understanding Pharmacodynamics of Butyl Isobutyl Phthalate: Where In vitro and In silico Studies Converge (Record no. 15778)
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control field | OSt |
005 - DATE AND TIME OF LATEST TRANSACTION | |
control field | 20211228104743.0 |
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fixed length control field | 211228b xxu||||| |||| 00| 0 eng d |
040 ## - CATALOGING SOURCE | |
Original cataloging agency | AIKTC-KRRC |
Transcribing agency | AIKTC-KRRC |
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9 (RLIN) | 15132 |
Author | RAGHAVENDRA, H. L. |
245 ## - TITLE STATEMENT | |
Title | Understanding Pharmacodynamics of Butyl Isobutyl Phthalate: Where In vitro and In silico Studies Converge |
250 ## - EDITION STATEMENT | |
Volume, Issue number | Vol.83(2), March-April |
260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
Place of publication, distribution, etc. | Mumbai |
Name of publisher, distributor, etc. | Indian Journal of Pharmaceutical Science |
Year | 2021 |
300 ## - PHYSICAL DESCRIPTION | |
Pagination | 271-277p. |
520 ## - SUMMARY, ETC. | |
Summary, etc. | Recent epidemiological studies suggest that postprandial hyperglycemia is an independent risk factor for cardiovascular disease. A human’s high carbohydrate diet majorly consists of a high carbohydrate diet and α-glucosidase is a glucosidase located in the brush border of the small intestine is involved in glycosidic cleavage of starch at α-glycosidic bonds. α-glucosidase inhibitors are a unique class of anti-diabetic drugs particularly useful in individuals with a high carbohydrate diet. α-glucosidase inhibitors works by competitively inhibiting the enzymeα-glucosidase at the brush border of the small intestines, thus delaying the digestion of complex carbohydrate and intestinal absorption of glucose. Hence, in the present study, the α-glucosidase inhibition activity of butyl isobutyl phthalate isolated from chloroform fraction ofRubus steudneri leaves investigated and its possible mechanism of action ascertained in silico . The compound was found to exhibit concentration-dependent inhibition of α-glucosidase with half-maximal inhibitory concentration value of 10.68 g/ml. The results of in vitro α-glucosidase inhibition assay for butyl isobutyl phthalate were promising and substantiated by molecular docking and molecular dynamics studies. |
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
9 (RLIN) | 4639 |
Topical term or geographic name entry element | PHARMACEUTICS |
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9 (RLIN) | 15133 |
Co-Author | BHARATH, R. |
773 0# - HOST ITEM ENTRY | |
Title | Indian journal of pharmaceutical sciences |
Place, publisher, and date of publication | New Delhi |
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URL | https://www.ijpsonline.com/articles/understanding-pharmacodynamics-of-butyl-isobutyl-phthalate-where-emin-vitroem-and-emin-silicoem-studies-converge.pdf |
Link text | Click here |
942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
Source of classification or shelving scheme | |
Koha item type | Articles Abstract Database |
Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Permanent Location | Current Location | Shelving location | Date acquired | Barcode | Date last seen | Price effective from | Koha item type |
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School of Pharmacy | School of Pharmacy | Archieval Section | 2021-12-28 | 2021-2022597 | 2021-12-28 | 2021-12-28 | Articles Abstract Database |