| 000 -LEADER |
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a |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20211230113148.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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211230b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
AIKTC-KRRC |
| Transcribing agency |
AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME |
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| 9 (RLIN) |
15228 |
| Author |
Aphrodite, Choumessi T. |
| 245 ## - TITLE STATEMENT |
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| Title |
Anti-obesity effects of the methanol extract of momordica foetida(cucurbitaceae) in male wistar rats |
| 250 ## - EDITION STATEMENT |
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| Volume, Issue number |
Vol.13(6) |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Place of publication, distribution, etc. |
M P |
| Name of publisher, distributor, etc. |
Innovare Academic Sciences Pvt Ltd |
| Year |
2021 |
| 300 ## - PHYSICAL DESCRIPTION |
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| Pagination |
31-35p. |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc. |
Objective: This study was designed to evaluate the effect of the methanol extract of M. foetida (MEMf) on high fat diet-induced obese male rats. Methods: Four groups (experimental groups) of 6 male Wistar rats each were fed with a high-fat diet (HFD) for 4 w and then treated with either distilled water (control group), MEMf (50 or 100 mg/kg) or the reference compound Atorvastatin (10 mg/kg) for 27days. The body weight was recorded every two daysResults: HFD induced an increase (P<0.05) in the body and liver weights and the relative abdominal fat pad of the animals in the experimental groups as compared to those in the normal diet group. Also, HFD in the experimental groups reduced (P<0.05) superoxide dismutase and catalaseactivities, glutathione levels and increased lipid peroxidation in the liver, heart and kidney as well as altered lipid profile (increased serum triglycerides, total cholesterol, low-density lipoproteins (LDL-C), very low-density lipoproteins (VLDL-C), decreased high-density lipoproteins (HDL-C), increased atherogenic index and coronary risk index), when compared to the normal diet animals. All altered parameters were subsequently normalized when obese rats received either MEMf (50 or100 mg/kg) or the reference drug . A fifth group made up of rats (normal diet group) not subjected to a HFD was used as a negative control for the HFD obese rats. The Lee index, lipid profile and antioxidant parameters were assessed using animal body weight and biochemical methods, respectively.Conclusion:This study demonstrates the potential of MEMf to normalize hyperlipidemia, oxidative stress and animal visceral organ weightsincreased by HFD in rats. Thus, M. foetidais an interesting medicinal plant that could be exploited as sources of anti-obesity agents. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| 9 (RLIN) |
4639 |
| Topical term or geographic name entry element |
PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| 9 (RLIN) |
15229 |
| Co-Author |
Nkwenti, Chi H. A. |
| 773 0# - HOST ITEM ENTRY |
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| International Standard Serial Number |
2656-0097 |
| Place, publisher, and date of publication |
Bhopal Innovare Academic Sciences Pvt Ltd |
| Title |
International journal of pharmacy and pharmaceutical science |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| URL |
https://innovareacademics.in/journals/index.php/ijpps/article/view/41207/24889 |
| Link text |
Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
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| Koha item type |
Articles Abstract Database |
