Evaluation of gastroprotective effects of methanol extract of tephrosia villosa against experimentally induced ulcers in wistar rats (Record no. 15996)

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control field OSt
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20220119115401.0
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fixed length control field 220119b xxu||||| |||| 00| 0 eng d
040 ## - CATALOGING SOURCE
Original cataloging agency AIKTC-KRRC
Transcribing agency AIKTC-KRRC
100 ## - MAIN ENTRY--PERSONAL NAME
9 (RLIN) 15492
Author Rawal, Pinkey
245 ## - TITLE STATEMENT
Title Evaluation of gastroprotective effects of methanol extract of tephrosia villosa against experimentally induced ulcers in wistar rats
250 ## - EDITION STATEMENT
Volume, Issue number Vol.13 (11)
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Place of publication, distribution, etc. Bhopal
Name of publisher, distributor, etc. Innovare Academic Sciences Pvt Ltd
Year 2021
300 ## - PHYSICAL DESCRIPTION
Pagination 20-23p.
520 ## - SUMMARY, ETC.
Summary, etc. Objective: The present research work was designed to investigate the gastroprotective potentials of methanol extract of Tephrosia villosa.

Methods: The aerial parts of Tephrosia villosa were dried under shade, powdered and deffated with petroleum ether and then marc leftover was subjected to methanol extraction using soxhlet apparatus using soxh-let apparatus. Antiulcer activity of methanol extract was determined against stress-induced and aspirin-induced ulcers in experimental animal models. The total number of ulcers formed, ulcer index, percentage inhibition, ulcerated area, protected area, pH and Total acidity were parameters in the study.

Results: Methanol extract of Tephrosia villosa at medium (200 mg/kg) and high (200 mg/kg) could significantly (P<0.01) reduced the total number of ulcers formed, ulcer index, ulcerated area and total acidity in therapeutic groups compared to vehicle control and thereby significantly (P<0.01) increased percentage inhibition of ulcers and protected area which was evident by the significant rise in pH of gastric content. The effect of extracts was dose-dependent and results were comparable to that of standard drug omeprazole.

Conclusion: The results obtained from the present work suggest that the methanol extract of Tephrosia villosa possess significant anti-ulcer potentials against experimentally induced ulcers in albino rats.
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM
9 (RLIN) 4774
Topical term or geographic name entry element PHARMACOLOGY
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9 (RLIN) 15493
Co-Author Ramesh C.
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9 (RLIN) 15048
Co-Author PRAMANIK, S.
773 0# - HOST ITEM ENTRY
Place, publisher, and date of publication Bhopal Innovare Academic Sciences Pvt Ltd
Title International journal of pharmacy and pharmaceutical science
International Standard Serial Number 2656-0097
856 ## - ELECTRONIC LOCATION AND ACCESS
URL https://innovareacademics.in/journals/index.php/ijpps/article/view/41277/25552
Link text Full Article
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          Circulation School of Pharmacy School of Pharmacy Archieval Section 2022-01-19 2022-0125 2022-01-19 2022-01-19 Articles Abstract Database
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